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Showing 61 - 70 of 254 results.

Spatial profiling of chromatin accessibility in mouse and human tissues

Source:

Nature

August 17, 2022

Here we describe a method for spatially resolved chromatin accessibility profiling of tissue sections using next-generation sequencing.
Efficient Cas9-based Genome Editing Using CRISPR Analysis Webtools in Severe Early-onset-obesity Patient-derived iPSCs

Source:

Current Protocols

August 11, 2022

Discovery of the CRISPR-associated protein Cas9 and its RNA-guided cleavage mechanism marks the beginning of a new era in genomic engineering by enabling the editing of a target region in the genome.
Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy

Source:

Nature communications

August 1, 2022

Our results uncover a unifying stress-response pathway causally linking Aβ42o-dependent structural remodeling of dendritic mitochondria to synaptic loss.
Potential ALS Treatment Emerges from Nerve Cells in a Dish

Source:

CUIMC newsroom

July 25, 2022

Today Hynek Wichterle, PhD, and his colleagues are tantalizingly close to bringing a new drug for amyotrophic lateral sclerosis (ALS) to market.
Replication stress impairs chromosome segregation and preimplantation development in human embryos

Source:

Cell

July 19, 2022

The findings provide new insights into the basic biology of human reproduction and in the long term could lead to improvements in the success rate of in vitro fertilization (IVF).
Study Finds Why Many IVF Embryos Fail to Develop

Source:

CUIMC newsroom

July 19, 2022

Researchers have found that most of these mistakes are due to spontaneous errors in DNA replication in the earliest phase of cell division.
Damon Runyon Cancer Research Foundation awards $4.2 million to top clinical investigators

Source:

Damon Runyon Cancer Research Foundation

July 6, 2022

Aaron Viny named one of five new Damon Runyon Clinical Investigators by the Damon Runyon Cancer Research Foundation.
CRISPR-AsCas12a Efficiently Corrects a GPR143 Intronic Mutation in Induced Pluripotent Stem Cells from an Ocular Albinism Patient

Source:

The CRISPR Journal

June 8, 2022

In this study, we present a high-performance CRISPR-Cas ribonucleoprotein strategy to permanently correct the GPR143 mutation in these patient-derived iPSCs.
In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells

Source:

Cell Stem Cell

June 2, 2022

Our assembloid approach enables in a modular way to upgrade or exchange extraembryonic tissues to access more advanced stages of post-attachment development while complying with ethical policies.
Activation of Nkx2.5 transcriptional program is required for adult myocardial repair

Source:

Nature communications

May 27, 2022

Nkx2.5 is a key causative transcription factor associated with human congenital heart disease and one of the earliest markers of cardiac progenitors.

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