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Aaron Viny featured in Cell Stem Cell's "Introductions to the Community: Early-Career Researchers in the Time of COVID-19"

Source:

Cell Stem Cell

COVID-19 has unfortunately halted lab work, conferences, and in-person networking, which is especially detrimental to researchers just starting their labs.
Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate

Source:

PNAS

We demonstrate that iBMECs lack functional attributes of ECs since they are deficient in vascular lineage genes while expressing clusters of genes related to the neuroectodermal epithelial lineage.
Zebrafish model for spondylo-megaepiphyseal-metaphyseal dysplasia reveals post-embryonic roles of Nkx3.2 in the skeleton

Source:

Development

We report adult viable nkx3.2 mutant zebrafish displaying cartilage overgrowth in place of a missing jaw joint, as well as severe dysmorphologies of the facial skeleton, skullcap and spine.
Bipotent Progenitors Do Not Require Androgen Receptor for Luminal Specification during Prostate Organogenesis

Source:

Stem Cell Reports

Androgen receptor (AR) plays a fundamental role in most aspects of adult prostate homeostasis, and anti-androgen therapy represents the cornerstone of prostate cancer treatment.

Latest News

Hepatic stellate and endothelial cells maintain hematopoietic stem cells in the developing liver

Source:

Journal of Experimental Medicine

November 5, 2020

Here, we genetically dissected the developing liver niche by systematically determining the cellular source of a key HSC niche factor, stem cell factor (SCF).
Crispr Gene Editing Can Cause Unwanted Changes in Human Embryos, Study Finds

Source:

The New York Times

October 31, 2020

Instead of addressing genetic mutations, the Crispr machinery prompted cells to lose entire chromosomes.
Scholars Profile: Emmanuelle Passegué: Seeking the Secrets of Blood Stem Cells

Source:

Rita Allen Foundation

October 30, 2020

Emmanuelle Passegué featured in the Rita Allen Foundation Scholar Profiles
Allele-Specific Chromosome Removal after Cas9 Cleavage in Human Embryos

Source:

Cell

October 30, 2020

Here, we evaluate repair outcomes of a Cas9-induced double-strand break (DSB) introduced on the paternal chromosome at the EYS locus, which carries a frameshift mutation causing blindness.
Lineage analysis reveals an endodermal contribution to the vertebrate pituitary

Source:

Science

October 23, 2020

In addition to known ectodermal contributions, we use lineage tracing and time-lapse imaging in zebrafish to identify an endodermal contribution to the ADH.
Core Facilty Profile: Columbia Stem Cell Initiative Stem Cell Core Facility

Source:

StemBook

October 23, 2020

The Stem Cell Core Facility is one of the two core facilities of the Columbia Stem Cell Initiative (CSCI), the major stem cell program at the Columbia University Irving Medical Center.