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Bipotent Progenitors Do Not Require Androgen Receptor for Luminal Specification during Prostate Organogenesis

Source:

Stem Cell Reports

Androgen receptor (AR) plays a fundamental role in most aspects of adult prostate homeostasis, and anti-androgen therapy represents the cornerstone of prostate cancer treatment.
A single-cell atlas of the mouse and human prostate reveals heterogeneity and conservation of epithelial progenitors

Source:

eLife

Here, we describe a comprehensive single-cell atlas of the adult mouse prostate epithelium, which displays extensive heterogeneity.
Lineage analysis reveals an endodermal contribution to the vertebrate pituitary

Source:

Science

In addition to known ectodermal contributions, we use lineage tracing and time-lapse imaging in zebrafish to identify an endodermal contribution to the ADH.
Allele-Specific Chromosome Removal after Cas9 Cleavage in Human Embryos

Source:

Cell

Here, we evaluate repair outcomes of a Cas9-induced double-strand break (DSB) introduced on the paternal chromosome at the EYS locus, which carries a frameshift mutation causing blindness.

Latest News

Hepatic stellate and endothelial cells maintain hematopoietic stem cells in the developing liver

Source:

Journal of Experimental Medicine

November 5, 2020

Here, we genetically dissected the developing liver niche by systematically determining the cellular source of a key HSC niche factor, stem cell factor (SCF).
Crispr Gene Editing Can Cause Unwanted Changes in Human Embryos, Study Finds

Source:

The New York Times

October 31, 2020

Instead of addressing genetic mutations, the Crispr machinery prompted cells to lose entire chromosomes.
Scholars Profile: Emmanuelle Passegué: Seeking the Secrets of Blood Stem Cells

Source:

Rita Allen Foundation

October 30, 2020

Emmanuelle Passegué featured in the Rita Allen Foundation Scholar Profiles
Core Facilty Profile: Columbia Stem Cell Initiative Stem Cell Core Facility

Source:

StemBook

October 23, 2020

The Stem Cell Core Facility is one of the two core facilities of the Columbia Stem Cell Initiative (CSCI), the major stem cell program at the Columbia University Irving Medical Center.
Scientists Synthesize Jawbones From Pig Fat

Source:

The New York Times

October 14, 2020

The bones are among the hardest to replace in the body. A trial of the new technique in humans is about to begin.
Tissue engineered autologous cartilage-bone grafts for temporomandibular joint regeneration

Source:

Science Translational Medicine

October 14, 2020

This study demonstrates the feasibility of TMJ regeneration using anatomically precise, autologous, living cartilage-bone grafts for functional, personalized total joint replacement.