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Severely Damaged Human Lungs Can Now Be Successfully Recovered

Source:

Columbia Engineering

Columbia Engineering and Vanderbilt researchers demonstrate that human lungs rejected for transplant can be recovered
Therapy in Rhodopsin-Mediated Autosomal Dominant Retinitis Pigmentosa

Source:

Cell

This review provides an update on RNA therapeutics and therapeutic editing genome surgery strategies and ongoing clinical trials for RHO-adRP,
Detection of base analogs incorporated during DNA replication by nanopore sequencing

Source:

Nucleic Acids Research

DNA synthesis is a fundamental requirement for cell proliferation and DNA repair, but no single method can identify the location, direction and speed of replication forks with high resolution.
Human NK cell deficiency as a result of biallelic mutations in MCM10

Source:

The Journal of Clinical Investigation

We report a cause of NKD resulting from compound heterozygous mutations in minichromosomal maintenance complex member 10 that impaired NK cell maturation in a child with fatal susceptibility to CMV.

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Establishment and characterization of two iPSC lines derived from healthy controls

Source:

Stem Cell Research

July 25, 2020

We have generated two iPSC lines from skin biopsies of two healthy individuals.
Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs

Source:

Nature Medicine

July 13, 2020

We demonstrate that acutely injured human lungs declined for transplantation can be recovered by cross-circulation of whole blood between explanted human lungs and a Yorkshire swine.
Precision metabolome reprogramming for imprecision therapeutics in retinitis pigmentosa

Source:

The Journal of Clinical Investigation

July 13, 2020

Retinitis pigmentosa (RP), the most common form of rod-cone dystrophy, is caused by greater than 3100 mutations in more than 71 genes.
Does the Key to Anti-ageing Lie in Our Bones?

Source:

The Guardian

July 4, 2020

Almost 15 years later, Gerard Karsenty would publish the first of a series of landmark papers that would revolutionize our perspective on bone and the skeleton in general.
Standardized reporter systems for purification and imaging of human pluripotent stem cell-derived motor neurons and other cholinergic cells

Source:

Neuroscience

June 30, 2020

Reliable and consistent pluripotent stem cell reporter systems for efficient purification and visualization of motor neurons are essential reagents for the study of normal motor neuron biology.
Reading frame restoration at the EYS locus, and allele-specific chromosome removal after Cas9 cleavage in human embryos

Source:

bioRxiv

June 18, 2020

The correction of disease-causing mutations in human embryos could reduce the burden of inherited genetic disorders in the fetus and newborn.