Skip to site alert. Skip to content

News

Top Stories

Chao Lu & Mijo Simunovic Receive Schaefer Scholar Award

Source:

CUIMC newsroom

Drs. Lu & Simunovic among five VP&S faculty to receive a Schaefer Scholar Award this year, recognizing scientists who have distinguished themselves in the science of human physiology.
Chia-Wei Cheng, PhD, Awarded V Foundation Grant

Source:

Columbia HICCC News

Chia-Wei Cheng, PhD, has recently been awarded a V Foundation grant for her innovative research in the interface of nutritional and gene regulatory networks in cancer.
Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production

Source:

Journal of Experimental Medicine

We found that myeloid-biased MPP3 are functionally and molecularly heterogeneous, with a distinct subset of myeloid-primed secretory cells with high endoplasmic reticulum volume and FcγR expression.
Dosage sensitivity to Pumilio1 variants in the mouse brain reflects distinct molecular mechanisms

RNA-binding proteins such as PUM1 regulate mRNA targets in various ways. But to understand their physiological functions we have to study their interactions as well as targets.

Latest News

CERT1 mutations perturb human development by disrupting sphingolipid homeostasis

Source:

Journal of Clinical Investigation (JCI)

April 25, 2023

A previously uncharacterized CERT1 domain enables its homeostatic inactivation, without which sphingolipid production goes unchecked; clinical severity reflects the degree of dysregulation
Collateral activity of the CRISPR/RfxCas13d system in human cells

Source:

Communications Biology

March 28, 2023

Here we show that RfxCas13d can cause collateral transcriptome destruction when targeting abundant reporter RNA and endogenous RNAs, resulting in proliferation defect in target cells.
A New Era of Hope for MDS Patients

Source:

Columbia HICCC News

March 27, 2023

Stavroula Kousteni, PhD, and Azra Raza, MD, share their ambitions as the leaders of Columbia's Edward P. Evans Center for Myelodysplastic Syndromes.
Predicting Immunotherapy Response in Head and Neck Cancer

Source:

Columbia HICCC News

March 15, 2023

We're actively exploring the complex interplay between the immune system, microenvironment and tumor to identify molecular targets for head and neck cancer, and other solid tumor treatments.
Simple, Fast, and Efficient Method for Derivation of Dermal Fibroblasts From Skin Biopsies

Source:

Current Protocols

March 13, 2023

We developed a fast and simple protocol to grow dermal fibroblasts from skin biopsies.
Noncoding translation mitigation

Source:

Nature

March 12, 2023

Here we integrate massively parallel analyses of more than 10,000 human genomic sequences and millions of random sequences with genome-wide CRISPR screens.