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Scientists Synthesize Jawbones From Pig Fat

Source:

The New York Times

The bones are among the hardest to replace in the body. A trial of the new technique in humans is about to begin.
Tissue engineered autologous cartilage-bone grafts for temporomandibular joint regeneration

Source:

Science Translational Medicine

This study demonstrates the feasibility of TMJ regeneration using anatomically precise, autologous, living cartilage-bone grafts for functional, personalized total joint replacement.
Core Facilty Profile: Columbia Stem Cell Initiative Stem Cell Core Facility

Source:

StemBook

The Stem Cell Core Facility is one of the two core facilities of the Columbia Stem Cell Initiative (CSCI), the major stem cell program at the Columbia University Irving Medical Center.
Research Ramps Up After Pause for Pandemic

Source:

Columbia University Irving Medical Center News

Returning Scientists Re-energized

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Identification of the skeletal progenitor cells forming osteophytes in osteoarthritis

Source:

The Annals of the Rheumatic Diseases

September 21, 2020

The aim of this study was to identify the cells forming osteophytes in OA.
The Alzheimer's disease‐associated C99 fragment of APP regulates cellular cholesterol trafficking

Source:

The EMBO Journal

August 31, 2020

The link between cholesterol homeostasis and cleavage of the amyloid precursor protein, and how this relationship relates to Alzheimer's disease pathogenesis, is still unknown.
Human NK cell deficiency as a result of biallelic mutations in MCM10

Source:

The Journal of Clinical Investigation

August 31, 2020

We report a cause of NKD resulting from compound heterozygous mutations in minichromosomal maintenance complex member 10 that impaired NK cell maturation in a child with fatal susceptibility to CMV.
Therapy in Rhodopsin-Mediated Autosomal Dominant Retinitis Pigmentosa

Source:

Cell

August 25, 2020

This review provides an update on RNA therapeutics and therapeutic editing genome surgery strategies and ongoing clinical trials for RHO-adRP,
Detection of base analogs incorporated during DNA replication by nanopore sequencing

Source:

Nucleic Acids Research

July 25, 2020

DNA synthesis is a fundamental requirement for cell proliferation and DNA repair, but no single method can identify the location, direction and speed of replication forks with high resolution.
Establishment and characterization of two iPSC lines derived from healthy controls

Source:

Stem Cell Research

July 25, 2020

We have generated two iPSC lines from skin biopsies of two healthy individuals.