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Here we report two distinct roles of Gon4l/Udu in heart development: regulation of cell proliferation and maintenance of ventricular identity.
Optogenetic genome engineering tools enable spatiotemporal control of gene expression and provide new insight into biological function.
Here we describe how selection for specific mutations that increase HSC competitive fitness, in conjunction with additional endogenous and environmental changes, drives leukaemic transformation.
Source:Investigative Ophthalmology & Visual Science
We tested whether sodium phenylbutyrate (4PBA) could rescue the function of mutant bestrophin 1 associated with autosomal dominant and recessive disease.
Source:Scientific ReportsDecember 13, 2020
Investigation and Restoration of BEST1 Activity in Patient-derived RPEs with Dominant Mutations
Source:Expert Opinion on Drug DiscoveryNovember 29, 2020
Neuromuscular Junctions (NMJs) are the synapses between motor neurons and skeletal muscle fibers, and they are responsible for voluntary motor function.
Source:Science DirectMay 6, 2020
In this short review, we draw parallels and stress differences between heart regeneration in mice and human, from a bioengineering perspective.
Source:Molecular Biology of the CellApril 30, 2020
Here we consider how changing migratory and adhesive phenotypes contribute to human natural killer (NK)- and T-cell development
Source:Frontiers in Bioengineering and BiotechnologyApril 15, 2020
We review recent advances in lung bioengineering that have potential to repair the epithelial and vascular compartments of the lung
Source:The Journal of Thoracic and Cardiovascular SurgeryApril 3, 2020
Multiday maintenance of extracorporeal lungs using cross-circulation with conscious swine