RNA-binding proteins such as PUM1 regulate mRNA targets in various ways. But to understand their physiological functions we have to study their interactions as well as targets.
Here we show that RfxCas13d can cause collateral transcriptome destruction when targeting abundant reporter RNA and endogenous RNAs, resulting in proliferation defect in target cells.
We're actively exploring the complex interplay between the immune system, microenvironment and tumor to identify molecular targets for head and neck cancer, and other solid tumor treatments.
Here we integrate massively parallel analyses of more than 10,000 human genomic sequences and millions of random sequences with genome-wide CRISPR screens.
We show that CPSF6 deficiency in human patients and zebrafish causes neurological, skeletal, and cardiovascular defects by altering poly(A) site choice to modulate protein levels during development.
