A study defined intestinal enteroendocrine cells with stem cell activity during both homeostatic renewal of the intestinal epithelium and regeneration following injury.
Leptin-receptor-positive mesenchymal stromal cells expand and are responsible for bone marrow fibrosis and targeting the PDGFRa pathway is effective in eliminating bone marrow fibrosis.
An engineering strategy produces novel recombinant surrogate agonists that upregulate canonical Wnt and beta-catenin signaling via forced heterodimerization of Frizzled and LRP receptors.
Studies of the behavior of Drosophila ovarian follicle stem cells reveal a new paradigm of immediate diversification of stem cell derivatives according to stem cell position in a larger population.
Interview with Emmanuelle Passegué, PhD, director of the Columbia Stem Cell Initiative and expert on hematopoietic stem cells (HSCs), blood-forming stem cells that originate in the bone marrow.
A recent mouse study, led by Emmanuelle Passegué, PhD and published in Nature, examines the role of hematopoietic stem cells (HSCs) in the aging process.
