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Showing 71 - 80 of 259 results.

Study Finds Why Many IVF Embryos Fail to Develop

Source:

CUIMC newsroom

July 19, 2022

Researchers have found that most of these mistakes are due to spontaneous errors in DNA replication in the earliest phase of cell division.
Damon Runyon Cancer Research Foundation awards $4.2 million to top clinical investigators

Source:

Damon Runyon Cancer Research Foundation

July 6, 2022

Aaron Viny named one of five new Damon Runyon Clinical Investigators by the Damon Runyon Cancer Research Foundation.
CRISPR-AsCas12a Efficiently Corrects a GPR143 Intronic Mutation in Induced Pluripotent Stem Cells from an Ocular Albinism Patient

Source:

The CRISPR Journal

June 8, 2022

In this study, we present a high-performance CRISPR-Cas ribonucleoprotein strategy to permanently correct the GPR143 mutation in these patient-derived iPSCs.
In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells

Source:

Cell Stem Cell

June 2, 2022

Our assembloid approach enables in a modular way to upgrade or exchange extraembryonic tissues to access more advanced stages of post-attachment development while complying with ethical policies.
Activation of Nkx2.5 transcriptional program is required for adult myocardial repair

Source:

Nature communications

May 27, 2022

Nkx2.5 is a key causative transcription factor associated with human congenital heart disease and one of the earliest markers of cardiac progenitors.
Fibroblast growth factor homologous factors serve as a molecular rheostat in tuning arrhythmogenic cardiac late sodium current

Source:

Nature Cardiovascular Research

May 16, 2022

Overall, these findings lend insights into molecular mechanisms underlying FHF regulation of INa,L in pathophysiology and outline potential therapeutic avenues.
CRISPR/Cas therapeutic strategies for autosomal dominant disorders

Source:

The Journal of Clinical Investigation

May 2, 2022

Here, we detail recent advancements in CRISPR therapeutics to treat a wide range of autosomal dominant disorders and discuss how they are altering the landscape for future therapies.
A multi-organ chip with matured tissue niches linked by vascular flow

Source:

Nature Biomedical Engineering

May 2, 2022

Vascularly linked and phenotypically stable matured human tissues may facilitate the clinical applicability of tissue chips.
Plug-and-Play Organ-on-a-Chip Can Be Customized to the Patient

Source:

Columbia Engineering News

April 27, 2022

A team of researchers from reports that they have essentially created a plug-and-play multi-organ chip, which is the size of a microscope slide, that can be customized to the patient.
Comprehensive analysis of DNA replication timing across 184 cell lines suggests a role for MCM10 in replication timing regulation

Source:

Human Molecular Genetics

April 25, 2022

This study demonstrates the remarkable robustness of the human replication timing program and reveals MCM10 as a novel candidate modulator of DNA replication timing.

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