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Showing 71 - 80 of 254 results.

Fibroblast growth factor homologous factors serve as a molecular rheostat in tuning arrhythmogenic cardiac late sodium current

Source:

Nature Cardiovascular Research

May 16, 2022

Overall, these findings lend insights into molecular mechanisms underlying FHF regulation of INa,L in pathophysiology and outline potential therapeutic avenues.
CRISPR/Cas therapeutic strategies for autosomal dominant disorders

Source:

The Journal of Clinical Investigation

May 2, 2022

Here, we detail recent advancements in CRISPR therapeutics to treat a wide range of autosomal dominant disorders and discuss how they are altering the landscape for future therapies.
A multi-organ chip with matured tissue niches linked by vascular flow

Source:

Nature Biomedical Engineering

May 2, 2022

Vascularly linked and phenotypically stable matured human tissues may facilitate the clinical applicability of tissue chips.
Plug-and-Play Organ-on-a-Chip Can Be Customized to the Patient

Source:

Columbia Engineering News

April 27, 2022

A team of researchers from reports that they have essentially created a plug-and-play multi-organ chip, which is the size of a microscope slide, that can be customized to the patient.
Comprehensive analysis of DNA replication timing across 184 cell lines suggests a role for MCM10 in replication timing regulation

Source:

Human Molecular Genetics

April 25, 2022

This study demonstrates the remarkable robustness of the human replication timing program and reveals MCM10 as a novel candidate modulator of DNA replication timing.
Pursuing totipotency: authentic totipotent stem cells in culture

Source:

Cell Press

April 18, 2022

Totipotent stem cells are transiently occurring in vivo cells that can form all cell types of the embryo including placenta, with their in vitro counterparts being actively pursued.
Kelley Yan & Aaron Viny 2 of 15 VP&S Physician-Scientists To Receive Early-Career Funding to Support Research

Source:

CUIMC newsroom

April 14, 2022

Kelley Yan and Aaron Viny among 15 who have been recognized as VP&S Promising Clinician Scientists and awarded grants from the Office of Academic Affairs to support their research.
Subversion of Serotonin Receptor Signaling in Osteoblasts by Kynurenine Drives Acute Myeloid Leukemia

Source:

Cancer Discovery

April 1, 2022

Remodeling of the microenvironment by tumor cells can activate pathways that favor cancer growth.
Quantifying Human Natural Killer Cell Migration by Imaging and Image Analysis

Source:

Methods in Molecular Biology

March 29, 2022

Here, we will describe techniques for the experimental setup and analysis of NK cell motility assays by confocal microscopy or in-incubator imaging using commercially available systems.
Two Columbia Cancer Researchers Honored by American Gastroenterological Association

Source:

Columbia HICCC News

March 21, 2022

Timothy Wang, MD, and Kelley Yan, MD, PhD, have each been awarded 2022 Annual Recognition Prizes from the American Gastroenterological Association (AGA).

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