We used transplantation, parabiosis, plasma transfer, exercise, calorie restriction, and aging mutant mice to understand the effects of age-regulated systemic factors on HSCs and bone marrow niche.
Macular degeneration (MD) is characterized by the progressive deterioration of the macula and represents one of the most prevalent causes of blindness worldwide.
We sought to identify a method of testing that would provide patient-specific information on whether a patient will respond to a medication using in vitro modeling.
We sought to identify a method of testing that would provide patient-specific information on whether a patient will respond to a medication using in vitro modeling.
Entering through angiotensin-converting enzyme 2 receptors,2 SARS-CoV-2 can damage endothelial cells leading to inflammation, thrombi, and brain damage.
We demonstrate that iBMECs lack functional attributes of ECs since they are deficient in vascular lineage genes while expressing clusters of genes related to the neuroectodermal epithelial lineage.