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Showing 251 - 259 of 259 results.

Genomic Instability During Reprogramming by Nuclear Transfer is DNA Replication Dependent

Source:

Nature Cell Biology

March 6, 2017

A study shows that genetic instability during cell type transitions and reprogramming is DNA replication dependent. This shows that DNA replication has an active role in shaping cell identity.
Multivalent Small-Molecule Pan-RAS Inhibitors

Source:

Cell

February 23, 2017

Using mass spectrometry to study the binding of the purine nucleoside GDP to mutant and wildtype KRAS protein.
In Some Genetic Cases of Microcephaly, Stem Cells Fail to Launch

Source:

CUMC Newsroom

August 24, 2016

In a very severe, genetic form of microcephaly, stem cells in the brain fail to divide, according to a study that may provide clues to understanding how the Zika virus affects the developing brain.
Scientists Generate a New Type of Human Stem Cell That Has Half a Genome

Source:

CUMC Newsroom

March 16, 2016

Scientists have succeeded in generating a new type of embryonic stem cell that carries a single copy of the human genome, instead of the two copies typically found in stem cells.
CRISPR Used to Repair Blindness-causing Genetic Defect in Patient-derived Stem Cells

Source:

CUMC Newsroom

January 27, 2016

Scientists have used a new gene-editing technology called CRISPR to repair a genetic mutation responsible for retinitis pigmentosa (RP).
Biomarker Predicts Which Stage II Colon Cancer Patients May Benefit from Chemotherapy

Source:

CUMC Newsroom

A biomarker has been identified by a multicenter research team that predicts which stage II colon cancer patients may benefit from chemotherapy after surgery to prevent a recurrence of their disease.

Topic

Cancer
Potent and Reversible Lentiviral Vector Restriction in Murine Induced Pluripotent Stem Cells

Source:

Retrovirology

This paper characterizes the block to infection of mouse induced pluripotent stem cells (iPSC) by HIV vectors. The findings are relevant to gene therapy approaches targeting these cells.
Differential Control of Retrovirus Silencing in Embryonic Cells by Proteasomal Regulation of the ZFP809 Retroviral Repressor

Source:

Proceedings of the National Academy of Sciences

This paper probes the mechanisms by which embryonic stem cells regulate the levels of ZFP809, the major repressor of murine leukemia virus gene expression.
CRISPR-Mediated Base Editing Enables Efficient Disruption of Eukaryotic Genes through Induction of STOP Codons

Source:

Molecular Cell

A new CRISPR-dependent approach to inactivate genes by inducing STOP codons by generating knockout alleles in stem cells without formation of potentially toxic DNA double-strand breaks.

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