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Showing 91 - 100 of 261 results.

CRISPR genome surgery in a novel humanized model for autosomal dominant retinitis pigmentosa

Source:

Cell Press

March 1, 2022

This study demonstrates the effectiveness of AR treatment of adRP in the human genomic context while revealing the feasibility of its application for other autosomal dominant disorders.
Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome

Source:

Nature Cardiovascular Research

February 22, 2022

Our study demonstrates that SIGMAR1 is a potential therapeutic target for Timothy syndrome and possibly other inherited arrhythmias such as LQTS1 and LQTS2.
Cough Suppressant Knocks Some Hearts Back into Rhythm

Source:

CUMC Newsroom

February 17, 2022

An over-the-counter cough suppressant can knock some heart cells back into rhythm, a finding that may lead to a new way to treat a rare heart condition called long QT syndrome.
Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer's disease

Source:

Brain

February 11, 2022

We show that tubulin tyrosine ligase hemizygous mice exhibit decreased tyrosinated microtubules, reduced dendritic spine density, and both synaptic plasticity and memory deficits.
Regeneration of Jaw Joint Cartilage in Adult Zebrafish

Source:

Frontiers in Cell and Developmental Biology

January 28, 2022

We performed single-cell RNA sequencing of the uninjured adult jaw joint and identified multiple skeletal, connective tissue, and fibroblast subtypes
Michael Shen One of Five Columbia Faculty Named AAAS Fellows

Source:

Columbia News

January 26, 2022

Columbia's 2021 AAAS Fellows are recognized for their contributions to teaching and research.
LA Times Today: How COVID changes the brain

January 19, 2022

Dr. Maura Boldrini, a neuroscientist at Columbia University, says new research could have far-reaching implications for other mental illnesses beyond COVID.
To Stop Blood Cancer, Target the Bone

Source:

CUIMC newsroom

January 19, 2022

To stop acute myeloid leukemia targeting neighboring bone cells may be a better strategy than directly targeting the cells that give rise to the disease, suggests a new Columbia study.
Lifelong single-cell profiling of cranial neural crest diversification in zebrafish

Source:

Nature communications

January 10, 2022

We observe progressive and region-specific establishment of enhancer accessibility for distinct fates
An expansion of the non-coding genome and its regulatory potential underlies vertebrate neuronal diversity

Source:

Neuron

January 5, 2022

Neuronal genes are associated with highly complex gene regulatory systems that reside in expanded non-coding genomic domains.

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