Chia-Wei Cheng, PhD, has recently been awarded a V Foundation grant for her innovative research in the interface of nutritional and gene regulatory networks in cancer.
Drs. Lu & Simunovic among five VP&S faculty to receive a Schaefer Scholar Award this year, recognizing scientists who have distinguished themselves in the science of human physiology.
We found that myeloid-biased MPP3 are functionally and molecularly heterogeneous, with a distinct subset of myeloid-primed secretory cells with high endoplasmic reticulum volume and FcγR expression.
A previously uncharacterized CERT1 domain enables its homeostatic inactivation, without which sphingolipid production goes unchecked; clinical severity reflects the degree of dysregulation
RNA-binding proteins such as PUM1 regulate mRNA targets in various ways. But to understand their physiological functions we have to study their interactions as well as targets.
Here we show that RfxCas13d can cause collateral transcriptome destruction when targeting abundant reporter RNA and endogenous RNAs, resulting in proliferation defect in target cells.
We're actively exploring the complex interplay between the immune system, microenvironment and tumor to identify molecular targets for head and neck cancer, and other solid tumor treatments.
Here we integrate massively parallel analyses of more than 10,000 human genomic sequences and millions of random sequences with genome-wide CRISPR screens.
