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Showing 141 - 150 of 254 results.

The Alzheimer's disease‐associated C99 fragment of APP regulates cellular cholesterol trafficking

Source:

The EMBO Journal

August 31, 2020

The link between cholesterol homeostasis and cleavage of the amyloid precursor protein, and how this relationship relates to Alzheimer's disease pathogenesis, is still unknown.
Human NK cell deficiency as a result of biallelic mutations in MCM10

Source:

The Journal of Clinical Investigation

August 31, 2020

We report a cause of NKD resulting from compound heterozygous mutations in minichromosomal maintenance complex member 10 that impaired NK cell maturation in a child with fatal susceptibility to CMV.
Therapy in Rhodopsin-Mediated Autosomal Dominant Retinitis Pigmentosa

Source:

Cell

August 25, 2020

This review provides an update on RNA therapeutics and therapeutic editing genome surgery strategies and ongoing clinical trials for RHO-adRP,
Chao Lu selected to share seed funding raised from Velocity, Columbia’s Ride to End Cancer

August 24, 2020

Chao Lu selected to share seed funding raised from Velocity, Columbia’s Ride to End Cancer
Detection of base analogs incorporated during DNA replication by nanopore sequencing

Source:

Nucleic Acids Research

July 25, 2020

DNA synthesis is a fundamental requirement for cell proliferation and DNA repair, but no single method can identify the location, direction and speed of replication forks with high resolution.
Establishment and characterization of two iPSC lines derived from healthy controls

Source:

Stem Cell Research

July 25, 2020

We have generated two iPSC lines from skin biopsies of two healthy individuals.
Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs

Source:

Nature Medicine

July 13, 2020

We demonstrate that acutely injured human lungs declined for transplantation can be recovered by cross-circulation of whole blood between explanted human lungs and a Yorkshire swine.
Precision metabolome reprogramming for imprecision therapeutics in retinitis pigmentosa

Source:

The Journal of Clinical Investigation

July 13, 2020

Retinitis pigmentosa (RP), the most common form of rod-cone dystrophy, is caused by greater than 3100 mutations in more than 71 genes.
Severely Damaged Human Lungs Can Now Be Successfully Recovered

Source:

Columbia Engineering

July 13, 2020

Columbia Engineering and Vanderbilt researchers demonstrate that human lungs rejected for transplant can be recovered
Does the Key to Anti-ageing Lie in Our Bones?

Source:

The Guardian

July 4, 2020

Almost 15 years later, Gerard Karsenty would publish the first of a series of landmark papers that would revolutionize our perspective on bone and the skeleton in general.

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