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How human embryonic stem cells sparked a revolution

Source:

Nature

March 28, 2018

After 20 years of hope, promise and controversy, human embryonic stem cells are reshaping biological concepts and starting to move into the clinic.
Alberto Ciccia, PhD, Assistant Professor of Genetics & Development has been named a 2018 Schaefer Research Scholar

Source:

CUMC Newsroom

March 12, 2018

Alberto Ciccia, PhD, Assistant Professor of Genetics & Development has been named a 2018 Schaefer Research Scholar
Kimara L. Targoff receives 2 recent grant awards

March 1, 2018

Saving Tiny Hearts Society- Mechanisms of cardiomyocyte renewal regulated by Nkx2.5 and Congenital Heart Defect Coalition- Mechanisms of Second Heart Field Development Regulated by crip Genes
A special Treg subset acts as stem cell protectants

Source:

Cell Stem Cell

March 1, 2018

Hirata et al has identified a unique regulatory T cell population which highly expresses a HSC marker (CD150), acting as stem cell protectants from immune attack and oxidative stress.
Bone Marrow Myeloid Cells Regulate Myeloid-Biased Hematopoietic Stem Cells via a Histamine-Dependent Feedback Loop

Source:

Cell Stem Cell

December 7, 2017

Hdc marks a population of myeloid-biased HSCs and progenitors
Recent book publication edited by Dr. Stephen Tsang

December 5, 2017

Precision Medicine, CRISPR, and Genome Engineering: Moving from Association to Biology and Therapeutics edited by Dr. Stephen Tsang
β-Cell Replacement in Mice Using Human Type 1 Diabetes Nuclear Transfer Embryonic Stem Cells

Source:

Diabetes

September 20, 2017

Lina Sui shows that stem cells matched to a patient with type 1 diabetes can be differentiated with high efficiency to beta cells, and can protect mice from diabetes.
Inter-homologue repair in fertilized human eggs?

Source:

bioRxiv

August 28, 2017

In this manuscript we point out the problem of the 'invisible allele' after gene editing in human embryos. Loss of a mutation is not equal to correction, and could instead be a new mutation.
Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-inducible Stem Cell Activity

Source:

Cell Stem Cell

July 6, 2017

A study defined intestinal enteroendocrine cells with stem cell activity during both homeostatic renewal of the intestinal epithelium and regeneration following injury.
Inhibition of CDK5 Alleviates the Cardiac Phenotypes in Timothy Syndrome

Source:

Stem Cell Reports

June 22, 2017

Yazawa’s laboratory elucidates the molecular mechanism underlying cardiac phenotypes in Timothy syndrome patient-derived cardiomyocytes using induced pluripotent stem cell technology.

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