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Showing 231 - 240 of 254 results.

Bone Marrow Myeloid Cells Regulate Myeloid-Biased Hematopoietic Stem Cells via a Histamine-Dependent Feedback Loop

Source:

Cell Stem Cell

December 7, 2017

Hdc marks a population of myeloid-biased HSCs and progenitors
Recent book publication edited by Dr. Stephen Tsang

December 5, 2017

Precision Medicine, CRISPR, and Genome Engineering: Moving from Association to Biology and Therapeutics edited by Dr. Stephen Tsang
β-Cell Replacement in Mice Using Human Type 1 Diabetes Nuclear Transfer Embryonic Stem Cells

Source:

Diabetes

September 20, 2017

Lina Sui shows that stem cells matched to a patient with type 1 diabetes can be differentiated with high efficiency to beta cells, and can protect mice from diabetes.
Inter-homologue repair in fertilized human eggs?

Source:

bioRxiv

August 28, 2017

In this manuscript we point out the problem of the 'invisible allele' after gene editing in human embryos. Loss of a mutation is not equal to correction, and could instead be a new mutation.
Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-inducible Stem Cell Activity

Source:

Cell Stem Cell

July 6, 2017

A study defined intestinal enteroendocrine cells with stem cell activity during both homeostatic renewal of the intestinal epithelium and regeneration following injury.
Inhibition of CDK5 Alleviates the Cardiac Phenotypes in Timothy Syndrome

Source:

Stem Cell Reports

June 22, 2017

Yazawa’s laboratory elucidates the molecular mechanism underlying cardiac phenotypes in Timothy syndrome patient-derived cardiomyocytes using induced pluripotent stem cell technology.
Leptin-receptor-expressing Bone Marrow Stromal Cells are Myofibroblasts in Primary Myelofibrosis

Source:

Nature Cell Biology

May 8, 2017

Leptin-receptor-positive mesenchymal stromal cells expand and are responsible for bone marrow fibrosis and targeting the PDGFRa pathway is effective in eliminating bone marrow fibrosis.
Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-related Macular Degeneration

Source:

Cell Stem Cell

May 4, 2017

Nicotinamide treatment helps to reduce the disease-related phenotypes and may represent a new treatment for patients with this blinding disease.
Non-equivalence of Wnt and R-spondin Ligands During Lgr5+ Intestinal Stem Cell Self-renewal

Source:

Nature

May 3, 2017

This study deconstructed the functional roles of Wnt and R-spondin ligands that coordinately regulated the Lgr5+ intestinal stem cell compartment.
Surrogate Wnt Agonists That Phenocopy Canonical Wnt and β-catenin Signalling

Source:

Nature

May 3, 2017

An engineering strategy produces novel recombinant surrogate agonists that upregulate canonical Wnt and beta-catenin signaling via forced heterodimerization of Frizzled and LRP receptors.

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