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Showing 241 - 250 of 254 results.

Alternative Direct Stem Cell Derivatives Defined by Stem Cell Location and Graded Wnt Signalling

Source:

Nature Cell Biology

April 17, 2017

Studies of the behavior of Drosophila ovarian follicle stem cells reveal a new paradigm of immediate diversification of stem cell derivatives according to stem cell position in a larger population.
5 Questions With Prof. Emmanuelle Passegué on Stem Cells

Source:

CUMC Newsroom

April 7, 2017

Interview with Emmanuelle Passegué, PhD, director of the Columbia Stem Cell Initiative and expert on hematopoietic stem cells (HSCs), blood-forming stem cells that originate in the bone marrow.
Stem Cells Are Immortal, But They Do Get Old

Source:

CUMC Newsroom

April 7, 2017

A recent mouse study, led by Emmanuelle Passegué, PhD and published in Nature, examines the role of hematopoietic stem cells (HSCs) in the aging process.
Myeloid Progenitor Cluster Formation Drives Emergency and Leukaemic Myelopoiesis

Source:

Nature

April 6, 2017

For the first time, the mechanism of hematopoietic stem cell (HSC) differentiation in the bone marrow niche is described.
Autophagy Maintains the Metabolism and Function of Young and Old Stem Cells

Source:

Nature

March 9, 2017

Study connects metabolic reprogramming with hematopoietic stem cell function, showing that a vast majority of aged blood stem cells exhibit changes in their metabolic activity.
Genomic Instability During Reprogramming by Nuclear Transfer is DNA Replication Dependent

Source:

Nature Cell Biology

March 6, 2017

A study shows that genetic instability during cell type transitions and reprogramming is DNA replication dependent. This shows that DNA replication has an active role in shaping cell identity.
Multivalent Small-Molecule Pan-RAS Inhibitors

Source:

Cell

February 23, 2017

Using mass spectrometry to study the binding of the purine nucleoside GDP to mutant and wildtype KRAS protein.
In Some Genetic Cases of Microcephaly, Stem Cells Fail to Launch

Source:

CUMC Newsroom

August 24, 2016

In a very severe, genetic form of microcephaly, stem cells in the brain fail to divide, according to a study that may provide clues to understanding how the Zika virus affects the developing brain.
Scientists Generate a New Type of Human Stem Cell That Has Half a Genome

Source:

CUMC Newsroom

March 16, 2016

Scientists have succeeded in generating a new type of embryonic stem cell that carries a single copy of the human genome, instead of the two copies typically found in stem cells.
CRISPR Used to Repair Blindness-causing Genetic Defect in Patient-derived Stem Cells

Source:

CUMC Newsroom

January 27, 2016

Scientists have used a new gene-editing technology called CRISPR to repair a genetic mutation responsible for retinitis pigmentosa (RP).

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