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Showing 241 - 250 of 259 results.

Inhibition of CDK5 Alleviates the Cardiac Phenotypes in Timothy Syndrome

Source:

Stem Cell Reports

June 22, 2017

Yazawa’s laboratory elucidates the molecular mechanism underlying cardiac phenotypes in Timothy syndrome patient-derived cardiomyocytes using induced pluripotent stem cell technology.
Leptin-receptor-expressing Bone Marrow Stromal Cells are Myofibroblasts in Primary Myelofibrosis

Source:

Nature Cell Biology

May 8, 2017

Leptin-receptor-positive mesenchymal stromal cells expand and are responsible for bone marrow fibrosis and targeting the PDGFRa pathway is effective in eliminating bone marrow fibrosis.
Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-related Macular Degeneration

Source:

Cell Stem Cell

May 4, 2017

Nicotinamide treatment helps to reduce the disease-related phenotypes and may represent a new treatment for patients with this blinding disease.
Non-equivalence of Wnt and R-spondin Ligands During Lgr5+ Intestinal Stem Cell Self-renewal

Source:

Nature

May 3, 2017

This study deconstructed the functional roles of Wnt and R-spondin ligands that coordinately regulated the Lgr5+ intestinal stem cell compartment.
Surrogate Wnt Agonists That Phenocopy Canonical Wnt and β-catenin Signalling

Source:

Nature

May 3, 2017

An engineering strategy produces novel recombinant surrogate agonists that upregulate canonical Wnt and beta-catenin signaling via forced heterodimerization of Frizzled and LRP receptors.
Alternative Direct Stem Cell Derivatives Defined by Stem Cell Location and Graded Wnt Signalling

Source:

Nature Cell Biology

April 17, 2017

Studies of the behavior of Drosophila ovarian follicle stem cells reveal a new paradigm of immediate diversification of stem cell derivatives according to stem cell position in a larger population.
5 Questions With Prof. Emmanuelle Passegué on Stem Cells

Source:

CUMC Newsroom

April 7, 2017

Interview with Emmanuelle Passegué, PhD, director of the Columbia Stem Cell Initiative and expert on hematopoietic stem cells (HSCs), blood-forming stem cells that originate in the bone marrow.
Stem Cells Are Immortal, But They Do Get Old

Source:

CUMC Newsroom

April 7, 2017

A recent mouse study, led by Emmanuelle Passegué, PhD and published in Nature, examines the role of hematopoietic stem cells (HSCs) in the aging process.
Myeloid Progenitor Cluster Formation Drives Emergency and Leukaemic Myelopoiesis

Source:

Nature

April 6, 2017

For the first time, the mechanism of hematopoietic stem cell (HSC) differentiation in the bone marrow niche is described.
Autophagy Maintains the Metabolism and Function of Young and Old Stem Cells

Source:

Nature

March 9, 2017

Study connects metabolic reprogramming with hematopoietic stem cell function, showing that a vast majority of aged blood stem cells exhibit changes in their metabolic activity.

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