A study shows that genetic instability during cell type transitions and reprogramming is DNA replication dependent. This shows that DNA replication has an active role in shaping cell identity.
In a very severe, genetic form of microcephaly, stem cells in the brain fail to divide, according to a study that may provide clues to understanding how the Zika virus affects the developing brain.
Scientists have succeeded in generating a new type of embryonic stem cell that carries a single copy of the human genome, instead of the two copies typically found in stem cells.
A biomarker has been identified by a multicenter research team that predicts which stage II colon cancer patients may benefit from chemotherapy after surgery to prevent a recurrence of their disease.
This paper characterizes the block to infection of mouse induced pluripotent stem cells (iPSC) by HIV vectors. The findings are relevant to gene therapy approaches targeting these cells.
This paper probes the mechanisms by which embryonic stem cells regulate the levels of ZFP809, the major repressor of murine leukemia virus gene expression.
A new CRISPR-dependent approach to inactivate genes by inducing STOP codons by generating knockout alleles in stem cells without formation of potentially toxic DNA double-strand breaks.
