Lina Sui shows that stem cells matched to a patient with type 1 diabetes can be differentiated with high efficiency to beta cells, and can protect mice from diabetes.
In this manuscript we point out the problem of the 'invisible allele' after gene editing in human embryos. Loss of a mutation is not equal to correction, and could instead be a new mutation.
A study defined intestinal enteroendocrine cells with stem cell activity during both homeostatic renewal of the intestinal epithelium and regeneration following injury.
Leptin-receptor-positive mesenchymal stromal cells expand and are responsible for bone marrow fibrosis and targeting the PDGFRa pathway is effective in eliminating bone marrow fibrosis.
An engineering strategy produces novel recombinant surrogate agonists that upregulate canonical Wnt and beta-catenin signaling via forced heterodimerization of Frizzled and LRP receptors.
Studies of the behavior of Drosophila ovarian follicle stem cells reveal a new paradigm of immediate diversification of stem cell derivatives according to stem cell position in a larger population.
Interview with Emmanuelle Passegué, PhD, director of the Columbia Stem Cell Initiative and expert on hematopoietic stem cells (HSCs), blood-forming stem cells that originate in the bone marrow.
