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Showing 161 - 170 of 259 results.

Small Molecules Restore Bestrophin 1 Expression and Function of Both Dominant and Recessive Bestrophinopathies in Patient-Derived Retinal Pigment Epithelium

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Investigative Ophthalmology & Visual Science

May 26, 2020

We tested whether sodium phenylbutyrate (4PBA) could rescue the function of mutant bestrophin 1 associated with autosomal dominant and recessive disease.
Dysregulated haematopoietic stem cell behaviour in myeloid leukaemogenesis

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Nature

May 15, 2020

Here we describe how selection for specific mutations that increase HSC competitive fitness, in conjunction with additional endogenous and environmental changes, drives leukaemic transformation.
Heart regeneration in mouse and human: a bioengineering perspective

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Science Direct

May 6, 2020

In this short review, we draw parallels and stress differences between heart regeneration in mice and human, from a bioengineering perspective.
Photoactivatable Cre recombinase 3.0 for in vivo mouse applications

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Nature

May 1, 2020

Optogenetic genome engineering tools enable spatiotemporal control of gene expression and provide new insight into biological function.
From stem cell to immune effector: how adhesion, migration, and polarity shape T-cell and natural killer cell lymphocyte development in vitro and in vivo

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Molecular Biology of the Cell

April 30, 2020

Here we consider how changing migratory and adhesive phenotypes contribute to human natural killer (NK)- and T-cell development
Bioengineering of Pulmonary Epithelium With Preservation of the Vascular Niche

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Frontiers in Bioengineering and Biotechnology

April 15, 2020

We review recent advances in lung bioengineering that have potential to repair the epithelial and vascular compartments of the lung
Multiday maintenance of extracorporeal lungs using cross-circulation with conscious swine

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The Journal of Thoracic and Cardiovascular Surgery

April 3, 2020

Multiday maintenance of extracorporeal lungs using cross-circulation with conscious swine
MERTK-Dependent Ensheathment of Photoreceptor Outer Segments by Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium

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Stem Cell Reports

March 10, 2020

Maintenance of a healthy photoreceptor-retinal pigment epithelium (RPE) interface is essential for vision.
How Safe Are Universal Pluripotent Stem Cells?

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Cell Stem Cell

March 5, 2020

Major breakthroughs in stem cell differentiation to therapeutically relevant cell types have led us to the doorstep of novel cell therapies that can replace disease management with a cure.
Fundoscopy-directed genetic testing to reevaluate negative whole exome sequencing results

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Orphanet Journal of Rare Diseases

March 3, 2020

Whole exome sequencing (WES) allows for an unbiased search of the genetic cause of a disease.

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