Publications

2023

Xu JJ, Viny AD. “Till SMARCA5 do nucleosomes part”, Molecular Cell 2023 Feb 16;83(4):500-501. PMID: 36804911.

2022:

Xu J, Song F, Lyu H, Kobayashi M, Zhang B, Zhao Z, Hou Y, Wang X, Luan Y, Jia B, Stasiak L, Wong JH, Wang Q, Jin Q, Jin Q, Fu Y, Yang H, Hardison RC, Dovat S, Platanias LC, Diao Y, Yang Y, Yamada T, Viny AD, Levine RL, Claxton D, Broach JR, Zheng H, Yue F. Subtype-specific 3D genome alteration in acute myeloid leukaemia, Nature, 2022 Nov;611(7935):387-398. PMID: 36289338

Stahl M, Derkach A, Farnoud N, Bewersdorf JP, Robinson T, Famulare C, Cho C, Devlin S, Menghrajani K, Patel MA, Cai SF, Miles LA, Bowman RL, Geyer MB, Dunbar A, Epstein-Peterson ZD, McGovern E, Schulman J, Glass JL, Taylor J, Viny AD, Stein EM, Getta B, Arcila ME, Gao Q, Barker J, Shaffer BC, Papadopoulos EB, Gyurkocza B, Perales MA, Abdel-Wahab O, Levine RL, Giralt SA, Zhang Y, Xiao W, Pai N, Papaemmanuil E, Tallman MS, Roshal M, Goldberg AD. Molecular predictors of immunophenotypic measurable residual disease clearance in acute myeloid leukemia. Am J Hematology, 2022 Oct 17. PMID: 36251406

Yeaton A, Cayanan G, Loghavi S, Dolgalev I, Leddin EM, Loo CE, Torabifard H, Nicolet D, Wang J, Corrigan K, Paraskevopoulou V, Starczynowski DT, Wang E, Abdel-Wahab O, Viny AD, Stone RM, Byrd JC, Guryanova OA, Kohli RM, Cisneros GA, Tsirigos A, Eisfeld AK, Aifantis I, Guillamot M. The impact of inflammation-induced tumor plasticity during myeloid transformation, Cancer Discovery, 2022 Aug 4. PMID: 35924979

Aivalioti MM, Bartholdy BA, Pradhan K, Bhagat TD, Zintiridou A, Jeong JJ, Thiruthuvanathan VJ, Pujato M, Paranjpe A, Zhang C, Levine RL, Viny AD, Wickrema A, Verma A, Will B. PU.1-dependent enhancer inhibition separated Tet2-deficient hematopoiesis from malignant transformation, Blood Cancer Discovery, 2022 Aug 1. PMID: 35820129

Meyer AE, Stelloh C, Pulakanti K, Burns R, Fisher JB, Heimbruch KE, Tarima S, Furumo Q, Brennan J, Zheng Y, Viny AD, Vassiliou GS, Rao S. Combinatorial genetics reveals the Dock1-Rac2 axis as a potential target for the treatment of NPM1;Cohesin mutated AML, Leukemia, Aug; 36(8):2032-2041. PMID: 35778533

Viny AD. “DNMT3A-Mutant Leukemia Cells Primed to “Fork It Over” under DNA Damage”, Clinical Cancer Research 2022 Feb 15;28(4):573-575. PMID: 34880109.

2021:

Bansal K, Michelson DA, Ramirez RN, Viny AD, Levine RL, Benoist C, Mathis D. Aire regulates chromatin looping by evicting CTCF from domain boundaries and favoring accumulation of cohesin on superenhancers, Proced Natl Acad Sci, 2021 Sept 21;118(38). PMID: 34518235

Rivas MA, Durmaz C, Kloetgen A, Chin CR, Chen Z, Bhinder B, Koren A, Viny AD, Scharer CD, Boss JM, Elemento O, Mason CE, Melnick AM. Cohesin Core Complex Gene Dosage Contributes to Germinal Center Derived Lymphoma Phenotypes and Outcomes, Frontiers in Immunology, 2021 Sept 21.

Smith C, Viny A, Massi E, Kandoth C, Socci N, Rapaport F, Najm M, Medina J, Papaemmanuil E, Tarver T, Hsu H, Le M, West B, Bollag G, Taylor B, Levine R, Shah N. Recurrent Mutations in Cyclin D3 Confer Clinical Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia, Clinical Cancer Research 2021 Jul 15:27(14):4003-4011. PMID: 34103301.

Viny AD. A Physician-Scientist’s call to arms, Cell Stem Cell 2021 May 6;28(5):799-801 PMID: 33961763.

Heimbruch KE, Meyer AE, Agrawal P, Viny AD, Rao S., A cohesive look at leukemogenesis: the cohesin complex and other driving mutations in AML, Neoplasia 2021 2021 Mar; 23(3):337-347 PMID: 33621854.

Heimbruch KE, Fisher JB, Stelloh CT, Phillips E, Reimer MH Jr, Wargolet AJ, Meyer AE, Pulakanti K, Viny AD, Loppnow JJ, Levine RL, Pulikkan JA, Zhu N, Rao S. DOT1L inhibitors block abnormal self-renewal induced by cohesin loss. Scientific Reports 2021 Mar 31;11(1):7288. PMID: 33790356

Rivas MA, Meydan C, Chin CR, Challman MF, Kim D, Bhinder B, Kloetgen A, Viny AD, Teater MR, McNally DR, Doane AS, Béguelin W, Calvo Fernández MT, Shen H, Wang X, Levine RL, Chen Z, Tsirigos A, Elemento O, Mason CE, Melnick AM. Smc3 dosage regulates B cell transit through geminal centers and restricts their malignant transformation. Nature Immunology 2021 Jan 11. PMID: 33432228.

2020:

Miles LA, Bowman RL, Merlinsky TR, Csete IS, Ooi A, Durruthy-Durruthy R, Bowman M, Famulare C, Patel MA, Mendez P, Ainali C, Manivannan M, Sahu S, Goldberg A, Bolton K, Zehir A, Rampal R, Carroll MP, Meyer SE, Viny AD, Levine RL. 2020. Single cell mutational profiling delineates clonal trajectories in myeloid malignancies. Nature 2020 October 28. PMID: 33116311

Pastore F, Bhagwat N, Pastore A, Radzisheuskaya A, Karzai A, Krishnan A, Li B, Bowman RL, Xiao W, Viny AD, Zouak A, Park YC, Cordner KB, Braunstein S, Maag JLV, Grego A, Mehta J, Wang M, Lin H, Durham BH, Koche RP, Rampal RK, Helin K, Scherle P, Vaddi K, Levine RL. PRMT5 inhibition modulates E2F1 methylation and gene regulatory networks leading to therapeutic efficacy in JAK2V617F mutant MPN. Cancer Discovery 2020 July 20. PMID: 32669286

Viny AD, Levine RL. Drug Modulation by Nuclear CondensatesScience. 2020 Jun 19; 6497(368): 1314-1315.

Izzo F, Lee SC, Poran A, Chaligne R, Gaiti F, Gross B, Murali RR, Deochand SD, Ang C, Jones PW, Nam AS, Kim KT, Kothen-Hill S, Schulman RC, Ki M, Lhoumaud P, Skok JA, Viny AD, Levine RL, Kenigsberg E, Abdel-Wahab O, Landau DA. DNA methylation disruption reshapes the hematopoietic differentiation landscape. Nature Genetics 2020 April 5. PMID: 32203468.

Kishtagari A, Levine RL, Viny AD. Driver Mutations in Acute Myeloid LeukemiaCurr Opin Hematol. 2020 March;27(2): 49-57. PMID: 31972687

Viny AD, Bowman RL, Liu Y, Lavallée VP, Eisman S, Xiao W, Durham B, Navitski A, Park J, Braunstein S, Alija B, Karzai A, Csete IS, Witkin M, Azizi E, Baslan T, Ott CJ, Pe’er D, Dekker J, Koche R, Levine RL. Cohesin members Stag1 and Stag2 display distinct roles in chromatin accessibility and topological control of HSC self-renewal and differentiationCell Stem Cell November 7, 25(5): 682-696 e688. PMID: 31495782

Pre-2020:

Viny AD, Levine RL. Cohesin mutations in myeloid malignancies made simpleCurr Opin Hematol. 2017 Dec 22. PubMed PMID: 29278534

Viny AD, Levine RL. Roads Diverge--A Robert Frost View of Leukemia Development. N Engl J Med. 2016 Jun 9;374(23):2282-4. PubMed PMID: 27276567.

van Galen P, Viny AD, Ram O, Ryan RJH, Cotton MJ, Donohue L, Sievers C, Drier Y, Liau BB, Gillespie SM, Carroll KM, Cross MB, Levine RL, Bernstein BE. A Multiplexed System for Quantitative Comparisons of Chromatin Landscapes. Molecular Cell. 2016 Jan 7 PMID:26687680

Viny AD*, Ott CJ*, Spitzer B, Rivas M, Meydan C, Papalexi E, Yelin D, Shank K, Reyes J, Chiu A, Romin Y, Boyko V, Thota S, Maciejewski JP, Melnick A, Bradner JE, Levine RL. Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis. Journal of Experimental Medicine, 2015 Oct 5 PMID: 2648361.  

Thota S*, Viny AD*, Makishima H, Spitzer B, Radivoyevitch T, Przychodzen B, Sekeres MA, Levine RL, Maciejewski JP. Genetic alterations of the cohesin complex genes in myeloid malignancies, Blood 2014 Sept 11;124(11): 1790-8. PMID: 25006131