Publications

Sudunagunta VS, Stewart EM, Chen Y, Yan H, Fernando S, Scoca V, Pantazi J, Deng R, Xu JJ, Mohandas N, Viny AD^#. Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome. Blood 2026 Aug 6; 148 (6): 767–782. PMID: 42148659

Song A, Chen Y, Iyer, SG, Fernando S, Sudunagunta VS, Stewart EM, Deng R, Scoca V, Xu JJ, May B, Varabyeva A, Hsiao SJ, Freeman C, Mansukhani M, Lipsky AH, Lamanna N, Rosenblat TL, Kasbekar M, Jurcic JG, Chernak B, Viny AD^#. Genetic predictors of clonal contraction and hematologic response in IDH mutant myeloid malignancies medRxiv 2026.

Udoh EO, Chen Y, D’Addona M, Stewart EM, Deng R, de Almeida Sartori F, Unlu S, Brady Z, Zhu R, Cheng, X, Scoca V, Xu JJ, Doulatov S, Theil K, Bosler DS, Visconte V, Maciejewski JM, Viny AD^# Multi-hit STAG2 mutations define a high-risk subset of MDS and reveal convergent evolutionary targeting of cohesin BioRxiv 2026.

Ku A and Viny AD^#. CNS Relapse During Menin Inhibitor Therapy. Blood 2026 Jul 9; 148(2):261. PMID: 42424054.

Bae SY, Chen Y, Chen H, Kumar D, Karaiskos S, Xu J, Lu C, Viny AD, DePinho R, Giancotti FG. Noncanonical Activity of Med4 as a Gatekeeper of Metastasis through Epigenetic Control of Integrin Signaling. Nature Cell Biology 2026. PMID: 42332201.

Dolsten G, Wang ZM, Huang X, Song S, Wilson MJ, Bing XY, Ke W, Cafiero TR, Nelson AN, Fernando S, Ploss A, Schedl P, Levine MS, Viny AD, Rudensky AY, Pritykin Y. Metadomain and metaloop genome interactions in mammalian T cells Cell Reports 2026. PMID: 42105235.

Iyer SG, Deng R, Jurcic JG, Varabyeva A, May BL, Fernando S, Lipsky A, Lamanna N, Rosenblat TL, Kasbekar M, Viny AD^#. Treatment-emergent coagulopathy during azacitadine/venetoclax induction in AML. Blood Neoplasia. 2026 Feb 21;3(2):100210. PMID: 41938746.

DuVall AS, McNeer J, Cheung MC, Adrianzen-Herrera DA, Advani AS, Aljurf M, Audino AN, Benitez L, Deeter A, Dworkin E, Hiltbrand OS, Isenalumhe LL, Li L, Miller-Chism CN, Mozessohn L, Ng AP, Pu JJ, Shafer D, Vargas Madueno F, Viny AD, Wadhwa A, Yang J, Zarnegar-Lumley S, Mai HJ, Kanaan G, Sereda Y, Saldanha IJ, Balk EM, Stock WA, Wolfson JA. ASH 2026 Guidelines for Frontline Management of Acute Lymphoblastic Leukemia in Adolescents and Young Adults. Blood Advances 2026 Feb 11. PMID: 41670627.

Sirenko M, Lee S, Sun Z, Chaligne R, Loghavi S, Asimomitis G, Brierley CK, Bernard E, Cai SF, Myers RM, Nadorp B, Sango J, Lallo M, Levine MF, Domenico D, Arango Ossa JE, Medina-Martinez JS, Menghrajani K, Lasry A, Mims AS, Desai H, Laganson A, Famulare C, Patel M, Lozanski G, Bolton KL, Viny AD, Roshal M, Levine RL, Papapetrou EP, Stein EM, Landau DA, Eisfeld AK, Aifantis I, Papaemmanuil E. Deconvoluting clonal and cellular architecture in IDH-mutant acute myeloid leukemia. Cell Stem Cell 2025 Jul 3;32(7):1102-1121. PMID: 40409258.

Gao VR, Yang R, Das A, Luo R, Luo H, McNally DR, Karagiannidis I, Rivas MA, Wang ZM, Barisic D, Karbalayghareh A, Wong W, Zhan YA, Chin CR, Noble WS, Bilmes JA, Apostolou E, Kharas MG, Béguelin W, Viny AD, Huangfu D, Rudensky AY, Melnick AM, Leslie CS. ChromaFold predicts the 3D contact map from single-cell chromatin accessibility. Nature Communications. 2025 Nov 1;15(1):9432. PMID: 39487131

Tolu SS, Viny AD, Amengual JE, Pro B, Bates SE. Getting the right combination to break the epigenetic code. Nature Reviews Clinical Oncology. 2024 Dec 2. PMID: 39623073

Sudunagunta VS and Viny AD^# Untangling the loops of Stag2 mutations in myelodysplastic syndrome Leukemia & Lymphoma. 2024 Sep 12:1-10. PMID: 39264305.

Xu JJ and Viny AD^# Chromatin Organization in Myelodysplastic Syndrome. Experimental Hematology. 2024 Apr 4;134:104216. PMID:38582293 

Lu Z, Wang Y, Assumcao FV, Liu P, Kopp A, Saka S, Mcilwain SJ, Viny AD, Brand M, Pan X. Yin Yang 1 regulated cohesin complex protein SMC3 in mouse hematopoietic stem cells. Blood Advances. 2024 Mar 26. PMID: 38531064.

Kubota Y and Viny AD^# Germline Predisposition to Clonal Hematopoiesis. Seminars in Hematology Seminars in Hematology. 2024 Feb;61(1):61-67. PMID: 38311514

Dunbar A, Bowman RL, Park Y, Izzo F, Myers RM, Karzai A, Kim WJ, Fernández Maestre I, Michael R. Waarts RJ, Nazir A, Xiao W, Brodsky M, Farina M, Cai L, Cai SF, Wang B, An W,  Yang JL, Mowla S, Eisman SE, Mishra T, Houston R, Guzzardi E, Martinez Benitez AR, Viny AD, Koche R, Landau DA, Levine RL. Jak2V617F Reversible Activation Shows an Essential Requirement for Jak2V617F in Myeloproliferative Neoplasms. Cancer Discovery 2024 Jan 12. PMID: 38230747.

Xu J, Song F, Lyu H, Kobayashi M, Zhang B, Zhao Z, Hou Y, Wang X, Luan Y, Jia B, Stasiak L, Wong JH, Wang Q, Jin Q, Jin Q, Fu Y, Yang H, Hardison RC, Dovat S, Platanias LC, Diao Y, Yang Y, Yamada T, Viny AD, Levine RL, Claxton D, Broach JR, Zheng H, Yue F. Subtype-specific 3D genome alteration in acute myeloid leukaemia, Nature, 2022 Nov;611(7935):387-398. PMID:36289338

Aivalioti MM, Bartholdy BA, Pradhan K, Bhagat TD, Zintiridou A, Jeong JJ, Thiruthuvanathan VJ, Pujato M, Paranjpe A, Zhang C, Levine RL, Viny AD, Wickrema A, Verma A, Will B. PU.1-dependent enhancer inhibition separated Tet2-deficient hematopoiesis from malignant transformation, Blood Cancer Discovery, 2022 Aug 1. PMID: 35820129

Meyer AE, Stelloh C, Pulakanti K, Burns R, Fisher JB, Heimbruch KE, Tarima S, Furumo Q, Brennan J, Zheng Y, Viny AD, Vassiliou GS, Rao S. Combinatorial genetics reveals the Dock1-Rac2 axis as a potential target for the treatment of NPM1;Cohesin mutated AML, Leukemia, Aug; 36(8):2032-2041. PMID: 35778533

Viny AD. “DNMT3A-Mutant Leukemia Cells Primed to “Fork It Over” under DNA Damage”, Clinical Cancer Research 2022 Feb 15;28(4):573-575. PMID: 34880109.

Bansal K, Michelson DA, Ramirez RN, Viny AD, Levine RL, Benoist C, Mathis D. Aire regulates chromatin looping by evicting CTCF from domain boundaries and favoring accumulation of cohesin on superenhancers, Proced Natl Acad Sci, 2021 Sept 21;118(38). PMID: 34518235

Smith C, Viny A, Massi E, Kandoth C, Socci N, Rapaport F, Najm M, Medina J, Papaemmanuil E, Tarver T, Hsu H, Le M, West B, Bollag G, Taylor B, Levine R, Shah N. Recurrent Mutations in Cyclin D3 Confer Clinical Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia, Clinical Cancer Research 2021 Jul 15:27(14):4003-4011. PMID: 34103301.

Viny AD. A Physician-Scientist’s call to arms, Cell Stem Cell 2021 May 6;28(5):799-801 PMID: 33961763.

Miles LA, Bowman RL, Merlinsky TR, Csete IS, Ooi A, Durruthy-Durruthy R, Bowman M, Famulare C, Patel MA, Mendez P, Ainali C, Manivannan M, Sahu S, Goldberg A, Bolton K, Zehir A, Rampal R, Carroll MP, Meyer SE, Viny AD, Levine RL. 2020. Single cell mutational profiling delineates clonal trajectories in myeloid malignancies. Nature 2020 October 28. PMID: 33116311

Viny AD, Levine RL. Drug Modulation by Nuclear Condensates. Science. 2020 Jun 19; 6497(368): 1314-1315 PMID: 32554584.

Izzo F, Lee SC, Poran A, Chaligne R, Gaiti F, Gross B, Murali RR, Deochand SD, Ang C, Jones PW, Nam AS, Kim KT, Kothen-Hill S, Schulman RC, Ki M, Lhoumaud P, Skok JA, Viny AD, Levine RL, Kenigsberg E, Abdel-Wahab O, Landau DA. DNA methylation disruption reshapes the hematopoietic differentiation landscape. Nature Genetics 2020 April 5. PMID: 32203468.

Kishtagari A, Levine RL, Viny AD. Driver Mutations in Acute Myeloid Leukemia. Curr Opin Hematol. 2020 March;27(2): 49-57. PMID: 31972687

Viny AD, Bowman RL, Liu Y, Lavallée VP, Eisman S, Xiao W, Durham B, Navitski A, Park J, Braunstein S, Alija B, Karzai A, Csete IS, Witkin M, Azizi E, Baslan T, Ott CJ, Pe’er D, Dekker J, Koche R, Levine RL. Cohesin members Stag1 and Stag2 display distinct roles in chromatin accessibility and topological control of HSC self-renewal and differentiation. Cell Stem Cell 2019 November 7, 25(5): 682-696 e688. PMID: 31495782

Viny AD, Levine RL. Cohesin mutations in myeloid malignancies made simple. Curr Opin Hematol. 2017 Dec 22. PubMed PMID: 29278534

Viny AD, Levine RL. Roads Diverge--A Robert Frost View of Leukemia Development. N Engl J Med. 2016 Jun 9;374(23):2282-4. PubMed PMID: 27276567.

van Galen P, Viny AD, Ram O, Ryan RJH, Cotton MJ, Donohue L, Sievers C, Drier Y, Liau BB, Gillespie SM, Carroll KM, Cross MB, Levine RL, Bernstein BE. A Multiplexed System for Quantitative Comparisons of Chromatin Landscapes. Molecular Cell. 2016 Jan 7 PMID:26687680

Viny AD*, Ott CJ*, Spitzer B, Rivas M, Meydan C, Papalexi E, Yelin D, Shank K, Reyes J, Chiu A, Romin Y, Boyko V, Thota S, Maciejewski JP, Melnick A, Bradner JE, Levine RL. Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis. Journal of Experimental Medicine, 2015 Oct 5 PMID: 2648361.  

Thota S*, Viny AD*, Makishima H, Spitzer B, Radivoyevitch T, Przychodzen B, Sekeres MA, Levine RL, Maciejewski JP. Genetic alterations of the cohesin complex genes in myeloid malignancies, Blood, 2014 Sept 11;124(11): 1790-8. PMID: 25006131