Viny Lab

Viny Lab

Location and Contact Information

650 West 168th Street
Room 1110
New York, NY 10032
United States
Open location 650 West 168th Street in Google Maps

Principal Investigator

  • Aaron D Viny, MD , MS

    Profile Headshot
    • Assistant Professor of Genetics & Development
    • Member, Columbia Stem Cell Initiative
    • Member, Cancer Genomics and Epigenomics Program, Herbert Irving Comprehensive Cancer Center
    • Assistant Director of Shared Resources, HICCC

Epigenetic Regulation and Chromatin Structure in Normal and Malignant Hematopoiesis

The Viny Lab studies how chromatin architecture and DNA methylation define the rules of genome interpretation, shaping when and where transcription factors act. We investigate how disruption of these rules in hematopoietic stem cells drives myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), and leverage these insights to develop epigenetically informed therapeutic strategies.  Mutations in chromatin regulators—including cohesin complex members—are among the most common lesions in MDS and AML, highlighting the central role of genome organization in hematologic malignancies. 


Our Lab studies how chromatin rules dictate when and how transcription factors become oncogenic—and how to therapeutically exploit that dependence. 

Back to top