Publications

2019

2018

  • Gaillard C, Surianarayanan S, Bentley T, Warr MR, Fitch B, Geng H, Passegué E, de Thé H, Kogan SC. Identification of IRF8 as a potent tumor suppressor in murine acute promyelocytic leukemia. Blood Adv., 2(19):2462-2466, 2018.
  • Leeman DS, Hebestreit K, Ruetz T, Webb AE, McKay A, Pollina EA, Dulken BW, Zhao X, Yeo RW, Ho TT, Mahmoudi S, Devarajan K, Passegué E, Rando TA, Frydman J, Brunet A. Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging. Science, 359:1277-1283, 2018.

2017

  • Hérault A, Binnewies M, Leong S, Calero-Nieto FJ, Zhang SY, Kang Y-A, Wang X, Pietras E, Chu SH, Barry-Holson K, Armstrong S, Göttgens B, Passegué E. Myeloid progenitor cluster formation drives emergency and leukemic myelopoiesis. Nature, 544:53-58, 2017.
  • Lefrançais E, Ortiz-Muñoz G, Caudrillier A, Mallavia B, Liu F, Sayah DM, Thornton EE, Headley MB, David T, Coughlin SR, Krummel MF, Leavitt AD, Passegué E, Looney MR. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature, 544:105-109, 2017.
  • Ho TT, Warr MR, Adelman E, Lansinger O, Flach J, Verovskaya E, Figueroa ME, Passegué E. Autophagy maintains metabolism and functional activity of a subset of aged hematopoietic stem cells. Nature, 543:205-210, 2017.
  • Beyaz S, Kim JH, Pinello L, Xifaras ME, Hu Y, Huang J, Kerenyi MA, Das PP, Barnitz RA, Hérault A, Dogum R, Haining WN, Yilmaz ÖH, Passegué E, Yuan GC, Orkin SH, Winau F. The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells. Nat Immunol, 18:184-195, 2017.

2016

  • Pietras M, Mirantes-Barbeito C, Fong S, Löeffler D, Kovtonyuk LV, Zhang SY, Lakshminarasimhan R, Chin CP, Techner J-M, Will B, Nerlov C, Steidl U, Manz MG, Schroeder T, Passegué E. Interleukin-1 drives hematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal. Nat Cell Biol, 18:607-618, 2016.
  • Chandel NS, Jasper H, Ho TT, Passegué E. Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing. Nat Cell Biol, 18:823-832, 2016.

2015

  • Schepers K, Campbell TB, Passegué E. Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities. Cell Stem Cell, 16:254-267, 2015
  • Ugarte F, Sousae R, Cinquin B, Martin EW, Krietsch J, Sanchez G, Inman M, Tsang H, Warr M, Passegué E, Larabell CA, Forsberg EC. Progressive Chromatin Condensation and H3K9 Methylation Regulate the Differentiation of Embryonic and Hematopoietic Stem Cells. Stem Cell Reports, 5:728-740, 2015.
  • Alvarez S, Díaz M, Flach J, Rodriguez-Acebes S, López-Contreras AJ, Martínez D, Cañamero M, Fernández-Capetillo O, Isern J, Passegué E, Méndez J. Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality. Nat Commun, 6:8548, 2015.
  • Wong JC, Weinfurtner KM, Alzamora MD, Kogan SC, Burgess MR, Zhang Y, Nakitandwe J, Ma J, Cheng J, Chen SC, Ho TT, Flach J, Reynaud D, Passegué E, Downing JR, Shannon K. Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis. Elife, Jul 20:4, 2015.
  • Pietras E*, Reynaud D*, Carlin D, Calero-Nieto FJ, Kang YA, Leavitt AD, Stuart JM, Gottgens B, Passegué E. Functionally distinct subsets of lineage-biased multipotent progenitors control blood production in normal and regenerative conditions. Cell Stem Cell, 17:35-46, 2015. (*equal contribution)
  • Gaillard C, Tokuyasu TA, Rosen G, Sotzen J, Vitaliano-Prunier A, Roy R, Passegué E, de Thé H, Figueroa ME, Kogan SC. Transcription and methylation analyses of preleukemic promyelocytes indicate a dual role for PML/RARA in leukemia initiation. Haematologica, 100:1064-1075, 2015.
  • Buchner M, Park E, Geng H, Klemm L, Flach J, Passegué E, Schjerven H, Melnick A, Paietta E, Kopanja D, Raychaudhuri P, Müschen M. Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia. Nat Commun, 6:6471, 2015.
  • Casbon AJ, Reynaud D, Park C, Khuc E, Gan DD, Schepers K, Passegué E, Werb Z. Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils. Proc Natl Acad Sci USA, 112:E566-75, 2015.

2014

  • Flach J, Bakker ST, Mohrin M, Conroy PC, Pietras EM, Reynaud D, Alvarez S, Diolaiti ME, Ugarte F, Forsberg EC, Le Beau MM, Stohr BA, Méndez J, Morrison CG, Passegué E. Replication stress is a potent driver of functional decline in aging hematopoietic stem cells. Nature, 512:198-202, 2014.
  • Mirantes C, Passegué E, Pietras EM. Pro-inflammatory cytokines: emerging players regulating HSC function in normal and diseased hematopoiesis. Exp Cell Res, 329:248-254, 2014.
  • Pietras EM, Lakshminarasimhan R, Techner JM, Fong S, Flach J, Binnewies M, Passegué E. Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons. J Exp Med, 211:245-262, 2014.
  • Kohli L, Passegué E. Surviving change: the metabolic journey of hematopoietic stem cells. Trends Cell Biol, 24:479-487, 2014.

2013

  • Schepers K, Pietras EM, Reynaud D, Flach J, Binnewies M, Garg T, Wagers AJ, Hsiao EC, Passegué E. Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche. Cell Stem Cell, 13:285-299, 2013.
  • Bakker ST, Passegué E. Resilient and resourceful: Genome maintenance strategies in hematopoietic stem cells. Exp Hematol, 41:915-923, 2013.
  • Li M, Jones L, Gaillard C, Binnewies M, Ochoa R, Garcia E, Lam V, Wei G, Yang W, Lobe C, Hermiston M, Passegué E, Kogan SC. Initially disadvantaged, TEL-AML1 cells expand and initiate leukemia in response to irradiation and cooperating mutations. Leukemia, 27:1570-1573, 2013.
  • Warr MR, Kohli L, Passegué E. Born to survive: autophagy in hematopoietic stem cell maintenance. Cell Cycle, 12:1979-1980, 2013.
  • Pietras EM, Passegué E. Linking HSCs to their youth. Nat Cell Biol, 15:885-887, 2013.
  • Warr MR, Binnewies M, Flach J, Reynaud D, Garg T, Malhotra R, Debnath J, Passegué E. FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature, 494:323-327, 2013.
  • Warr M, Passegué E. Metabolic makeover for HSCs. Cell Stem Cell, 12:1-3, 2013.

2012

  • Schepers K, Hsiao K, Garg T, Scott MJ, Passegué E. Activated Gs signaling in osteoblastic cells alters the hematopoietic stem cell niche in mice. Blood, 120:3425-3435, 2012.
  • Smith-Berdan S, Schepers K, Ly A, Passegué E, Forsberg EC. Dynamic expression of the Robo ligand Slit2 in bone marrow cell populations. Cell Cycle, 11:675-682, 2012.
  • Blanpain C, Daley GQ, Hochedlinger K, Passegué E, Rossant J, Yamanaka S. Stem Cells assessed. Nat Rev Mol Cell Biol, 13:471-476, 2012.

2011

  • Pietras EM, Warr M, Passegué E. Cell cycle regulation in hematopoietic stem cells. J Cell Biol, 195:709-720, 2011.
  • Reynaud D, Pietras EM, Barry-Holson K, Mir A, Binnewies M, Jeanne M, Sala-Torra O, Radich JP, Passegué E. IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development. Cancer Cell, 20:661-673, 2011.
  • Warr M, Pietras EM, Passegué E. Mechanisms controlling HSC functions during normal hematopoiesis and hematological malignancies. Wiley Interdiscip Rev. Syst. Biol. Med, 3:681-701, 2011.
  • Garcia D, Warr MR, Martins CP, Brown Swigart L, Passegué E, Evan GI. Validation of MdmX as a therapeutic target for reactivating p53 in tumors. Genes Dev, 25:1746-1257, 2011.
  • Blanpain C, Mohrin M, Sotiropoulou P, Passegué E. DNA damage response in tissue-specific and cancer stem cells. Cell Stem Cell, 8:16-29, 2011.

2010

  • Subramanyam D, Belair CD, Barry-Holson K, Lin H, Kogan SC, Passegué E, Blelloch R. PML-RARα and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia. Cancer Res, 70:8792-8801, 2010.
  • Elefanty AG, Blelloch R, Passegué E, Werning M, Mummery CL. On the Street of San Francisco: highlights from the ISSCR Annual Meeting 2010. Cell Stem Cell, 7:443-450, 2010.
  • Ragu C, Elain G, Mylonas E, Ottolenghi C, Cagnard N, Daegelen D, Passegué E, Vainchenker W, Bernard OA, Penard-Lacronique V. The transcription factor SRF regulates hematopoietic stem cell adhesion. Blood, 116:4464-4473, 2010.
  • Mohrin M, Bourke E, Alexander D, Warr M, Barry-Holson K, LeBeau M, Morrison CG, Passegué E. Hematopoietic stem cell quiescence promotes error prone DNA repair and mutagenesis. Cell Stem Cell, 7:174-485, 2010.
  • Forsberg EC, Passegué E, Prohaska SS, Wagers AJ, Koeva M, Stuart JM, Weissman IL. Molecular signatures of quiescent, mobilized and leukemia-initiating hematopoietic stem cells. PlosOne, 5:e8785, 2010.

2009

  • Santaguida M, Schepers K, King B, Sabnis AJ, Forsberg EC, Attema JL, Braun BS, Passegué E. JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal. Cancer Cell, 15:341-352, 2009.
  • Passegué E, Rafii S, Herlyn M. Cancer stem cells are everywhere. Nat Medicine, 15:53, 2009.
  • Sabnis AJ, Cheung LS, Dail M, Kang HC, Santaguida M, Hermiston ML, Passegué E, Shannon K, Braun BS. Oncogenic Kras Initiates Leukemia in Hematopoietic Stem Cells. PLoS Biol, 7(3):e59, 2009.
  • Passegué E, Ernst P. INF-alpha wakes up sleeping hematopoietic stem cells. Nat Medicine, 15:612-613, 2009.

2008

  • Viatour P, Somervaille T, Venkatasubrahmanyam S, Kogan K, McLaughlin M, Weissman IL, Butte A, Passegué E, Sage J. Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family. Cell Stem Cell, 3:416-428, 2008.
  • Shen W-F, Hu Y-L, Uttarwar L, Passegué E, Largman C. MicroRNA-126 Regulates HOXA9 by Binding to the Homeobox. Mol Cell Biol, 28:4609-4619, 2008.
  • Min IM, Pietramaggiori G, Kim FS, Passegué E, Stevenson KE, Wagers AJ. The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells. Cell Stem Cell, 2:380-391, 2008.
  • Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passegué E, Song H, VandenBerg S, Werb Z, Bergers G. HIF1a induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell, 13:206-220, 2008.

2007

  • Hu Y-L, Passegué E, Fong S, Largman C, Lawrence HJ. Evidence that the Pim1 kinase gene is a direct target of HOXA9 and a mediator of HOXA9's effects on hematopoiesis. Blood, 109:4732-4738, 2007.
  • Tothova Z, Kollipara R, Huntly BJ, Lee BH, Castrillon DH, Cullen DE, McDowell EP, Lazo-Kallanian S, Williams IR, Sears C, Armstrong SA, Passegué E, DePinho RA, Gilliland DG. FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress. Cell, 128:325-339, 2007.
  • Van Meter ME, Diaz-Flores E, Archard JA, Passegué E, Irish JM, Kotecha N, Nolan GP, Shannon K, Braun BS. K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells. Blood, 109:3945-3952, 2007.
  • Rajasekhar VK, Dalerba P, Passegué E, Lagasse E, Najbauer J. Stem Cells, Cancer, and Context Dependence. Stem Cells, 26:292-298, 2007.

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