Members

Faculty

  • Amélie Collins, MD, PhD

    Assistant Professor

    Dr. Collins received her MD and PhD degrees from New York University School of Medicine. Her graduate studies with Dr. Dan Littman focused on the regulation of gene expression during T cell development. She then moved to Columbia University Medical Center for Pediatrics Residency and Neonatal-Perinatal Fellowship. During that time, she pursued postdoctoral work in the lab of Dr. Steven Reiner, investigating human fetal natural killer cell development. Dr. Collins recently became an Assistant Professor in Pediatrics with clinical responsibilities in the Neonatal Intensive Care Unit, and joined the Passegué lab for a second postdoctoral fellowship. Her research is focused on evaluating the biology of hematopoietic stem and progenitor cells in the fetus and newborn, during normal development and in response to inflammation and infection, with the goal of improving our understanding of the pathogenesis of many conditions seen in the neonatal period.

Postdoctoral Fellows

  • Yoon A Kang, PhD

    Postdoctoral Research Fellow

    Yoona earned her BA in Biology at Yonsei University, Seoul, Korea. During her Master’s degree in the laboratory of Dr. Chae-ok Yun, she developed a novel anticancer therapy using an artificial transcription factor targeting VEGF promoter and oncolytic adenovirus. For her PhD training, she joined the laboratory of Dr. Emery Bresnick at the University of Wisconsin, Madison where she studied how the GATA factor pathway regulates erythropoiesis. Yoona graduated in June of 2013 and then joined the laboratory of Dr. Emmanuelle Passegué to start her postdoctoral training. Her current research projects focus on characterizing the biology of novel multipotent progenitor (MPP) populations in physiological and pathophysiological conditions. When not in the lab, she enjoys the outdoors and museums.

  • Oakley Olson, PhD

    Postdoctoral Research Fellow

    Oakley received his B.S. in biochemistry and molecular biology from Brown University in 2006. He then worked as a technician at Stanford University in the lab of Steven Foung, investigating humoral immune response to HCV and H5N1. From this experience, Oakley developed a keen interest in studying disease pathogenesis and moved on to Memorial Sloan Kettering Cancer Center, where he received his Ph.D. in 2016. There he worked in the lab of Johanna Joyce studying tumor-myeloid interactions, specifically the role of tumor-associated macrophages in chemoresistance and obesity-associated neutrophilia in promoting breast to lung metastasis. In 2018 Oakley Joined the Passegué lab where he is now investigating how stress dynamically alters myeloid progenitors to increase the output of specific mature populations. Combining single-cell RNA sequencing expression analysis, lineage tracing, single-cell differentiation assays, and immunofluorescence of the bone marrow microenvironment his research seeks to identify the mechanisms by which emergency myelopoiesis alters developmental trajectories and how this contribute to phenotypic heterogeneity in the mature myeloid compartment. Given that aberrant myelopoiesis is implicated in the pathogenesis of many diseases, from cardiovascular disease to cancer, understanding these regulatory mechanisms has significant translational potential.

Students

  • Paul Dellorusso

    PhD Graduate Student

    Paul grew up on Long Island and earned his bachelor’s degree in Molecular and Cellular Biology from Dartmouth in 2012. Following graduation, he spent four years working in biotechnology venture capital, business development, and management consulting roles in San Francisco and Boston. In 2016, he entered the Integrated Program in Cellular, Molecular, and Biomedical Studies at CUMC, and joined the Passegué lab thereafter. Paul is researching mechanisms of HSC aging, studying molecular processes that can be targeted to promote functional longevity of the hematopoietic system and forestall age-related diseases.

  • Carl Mitchell

    PhD Graduate Student

    Carl earned a B.A. in biochemistry and a B.M. in jazz performance from Oberlin College & Conservatory in 2015. He then spent three years as a research assistant in Gunter Blobel's laboratory at The Rockefeller University, an experience which confirmed his passion for biological research and inspired him to pursue his doctoral studies here at CUMC. Since joining the Passegué lab in 2019, his work has focused on investigating the functional decline of hematopoietic stem cells with age. Specifically, he hopes to further characterize pathways implicated in features of DNA damage and replication stress observed in old HSCs.

     

Staff

  • Silvere Pagant, PhD

    Laboratory Manager/Associate Research Scientist

  • Vincent Tem

    Technician

    Vincent earned his BA in Biology from New York University in 2018. He proceeded to earn his MSc in Integrated Immunology from the University of Oxford. During his time there, Vincent worked in the lab of Alexander Douglas at the Jenner Institute, where he developed antigen transgene improvements for a rabies viral-vectored vaccine. To continue following his passion in research as well as gain more experience, he joined the Passegué lab as a research technician in 2019. He plans to pursue MD/PhD programs in the future.