The Claudia Doege lab at Columbia University Irving Medical Center in New York City is seeking a highly motivated Postdoctoral Research Scientist with expertise in stem cell and/or neurobiology to study the molecular genetics of Prader-Willi syndrome. This work will involve creation and molecular characterization of mutation-specific human stem cell-derived hypothalamic organoids.  

Qualifications: 

1. Experience and knowledge in human stem cell biology and/or neurobiology.
2. Ability to work independently and as part of a team.
3. Excellent written and oral communication skills in English.
4. Record of productive research. 
5. Education: Ph.D. and/or M.D. 

Salary is competitive and will be based on qualifications.

Applicants should send curriculum vitae, statement of interest, and contact information for three references to:

Benedetta Spina, bs2839@cumc.columbia.edu 

The Kelley Yan Lab at Columbia University Irving Medical Center in New York City seeks to hire a fulltime postdoctoral fellow to conduct research in intestinal stem cell biology.  The Yan Lab studies intestinal stem cell biology using multi-disciplinary approaches including mouse genetics, biochemistry, single-cell genomics and organoid platforms.  We investigate the behavior of intestinal stem cells in regeneration of the intestinal epithelium during health and disease, as well as how to manipulate them for therapeutic benefit.  We are located in the Columbia Center for Human Development, Department of Medicine/Division of Digestive and Liver Diseases.  We are also part of the Department of Genetics & Development and the Columbia Stem Cell Initiative.  Suitable candidates must have a PhD, MD or MD/PhD degree and prior experience in developmental biology or stem cell biology.  Ideal candidates should have experience with mouse models, flow cytometry, microscopy, and basic molecular biology techniques.  Computational skills are a plus.  We seek to hire an individual with high energy and ambition, excellent communication skills, and strong desire for collaboration.  In return, we are eager to provide additional scientific training and individual career mentorship.  Please send a CV, cover letter summarizing past research and career goals, and names and contact information for three references to Dr. Kelley Yan.

Email: ky2004@cumc.columbia.edu

Website: www.yanlabcolumbia.com

There is currently a postdoc position available in Dr. Andrew Sproul’s lab to help generate human pluripotent stem cell (PSC) models of Alzheimer’s disease (AD) and to interrogate recently identified genetic factors that are correlated with decreased risk of AD. Specific familial and late-onset AD risk factors will be knocked into control PSC backbones using CRISPR/Cas9 technology. These isogenic PSC lines will subsequently be differentiated into disease-relevant cell types in both monolayer and organoid formats for functional assays. Differentiation strategies include overexpression of transcription factors by lentiviral transduction. CRISPR activation will be used to modulate expression of protective genetic factors. As these will be very collaborative projects with other research groups within the Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, good communication skills are essential for this position.

Strong cell culture experience and previous molecular biology work are required. Preference will be given to candidates with stem cell, primary neuronal culture, or genome editing experience. Please include an updated CV and cover letter with the application."

Apply here

Position Summary: The goal of this project is to define the requirement for the eukaryotic DNA helicase in human natural killer (NK) cell development. This project arises from the study of human NK cell deficiency, and we have extensive experience in the use of primary human cells to model and manipulate human NK cell development in vitro. Positions are currently open on an NIH-funded project with the aim of understanding why mutations in the eukaryotic DNA helicase lead to isolated human NK cell deficiency and extreme susceptibility to viral infection and malignancy.

What we offer:

• A supportive environment with the opportunity for intellectual and professional growth
• Opportunities to gain experience in cutting edge genetic and cell biological techniques, including in vitro modeling of human immune cell differentiation
• Excellent environment and resources at Columbia University in New York NY
• Fully funded position (renewed annually for up to 5 years)

What we seek:

• Collaborative, ambitious individuals with a strong interest in our research and environment
• Ability to work independently to develop research projects and mentor others
• Fearlessness in the design and implementation of new techniques and approaches to model human immune cell function
• Strong verbal and written communication skills
• Experience with human immune cells an asset

Application Materials:

• CV
• Cover letter including a paragraph describing how your research interests fit with the job described
• Contact information for 3 references

Email to: em3375@cumc.columbia.edu

CUIMC is an equal opportunity employer and we are proud to promote and cultivate diversity in science.

Position Summary: We study the cell biology of human immune cells using biochemistry, biophysics and multiscale, multidimensional quantitative imaging and analyses. Our overarching goal is to dissect the contact-dependent mechanisms that drive the maturation of human natural killer (NK) cells and the role that cell migration plays in these processes. We have extensive experience in the use of primary human cells to model and manipulate human NK cell development in vitro. Positions are currently open on an NIH-funded project with the aim of defining the requirement for cell migration and NK-stromal cell interactions in human NK cell development.

What we offer:

• A supportive environment with the opportunity for intellectual and professional growth
• Opportunities to gain experience in cutting edge cell biological and biophysical techniques, particularly high- and super-resolution microscopy and image analysis
• Excellent environment and resources at Columbia University in New York NY
• Fully funded position (renewed annually for up to 5 years)

What we seek:

• Collaborative, ambitious individuals with a strong interest in our research and environment
• Ability to work independently to develop research projects and mentor others
• Fearlessness in the design and implementation of new techniques and approaches to model human immune cell function
• Strong verbal and written communication skills
• Computational background is an asset

Application Materials:

• CV
• Cover letter including a paragraph describing how your research interests fit with the job described
• Contact information for 3 references

Email to: em3375@cumc.columbia.edu

CUIMC is an equal opportunity employer and we are proud to promote and cultivate diversity in science.