The Johnston Lab at Columbia University in New York is looking for curious and motivated individuals to join us in research that aims to characterize new molecular targets and pathways that provide plasticity to growing tissues, allowing cells to sense and adapt to changes in their immediate environment.

Several projects are available, including identification of sensors and mediators of cellular fitness, and investigating the role of competitive cell-cell interactions in organ size control and bilateral symmetry, and modelling the very early steps of cancer. Our work combines classical genetics, functional transcriptomics and genomics and biochemical analysis of cell biological processes, and we use Drosophila as our primary model organism. 

Columbia University Medical Center is renowned for its dedication to high-class biomedical research, with state-of-the-art facilities for functional genomics, proteomics and metabolomics, and offers a friendly, international and exciting scientific environment in New York City. 

Candidates should ideally have experience in one or more of the following disciplines: genetics, developmental cell biology, transcriptomics, functional genomics, protein biochemistry. Previous experience with Drosophila would provide an advantage.

For more information about the research projects and the application process, please contact Dr. Laura Johnston at  lj180@columbia.edu

Fellowship in Mood, Anxiety and Related Disorders

This is a two- to three-year training fellowship in clinical and basic research on mood, anxiety and related disorders. It is supported by a NIMH grant, and offers didactic methodological and statistical training as well as a supervised research experience. There are eight positions in the fellowship. Two to three new fellows enter each year. See full details here

Eligibility

MD with completed psychiatric or neurological residency, or PhD

U.S. citizen or permanent resident

Contact

Steven P. Roose, MD, spr2@cumc.columbia.edu 

Deadline: November 30 (For receipt of fully completed applications)

[See Application]

Janssen Fellowship in Translational Neuroscience Research

The Paul Janssen Fellowship is awarded annually to an outstanding young physician-investigator (must have M.D. or Ph.D. degree) to conduct novel translational research in the field of neuroscience as it relates to psychiatric disease and medicine. The Paul Janssen Fellow will be assigned both a basic scientist mentor and a clinical investigator mentor from the faculty at Columbia University to serve as joint mentors. The fellow will take a basic observation made by the basic science mentor and apply it to the study of disease or treatment with the clinical research mentor. See full details here.

Funding

The award provides a stipend, commensurate with experience. The stipend provided may require supplemental funding by the mentors.

Length of Fellowship

For one year, and potentially renewable for a second year based on performance.

Eligibility

Candidates from the international neuroscience community, holding an M.D. or Ph.D. degree, and preferably having completed initial fellowship research training, are invited to apply. Fellows at Columbia University or the New York State Psychiatric Institute/RFMH are encouraged to submit applications. **Faculty are not eligible.

Application

Preliminary Application Process (by November 2019): The following should be provided in 12 point font (or larger) with a minimum of one-inch margins: 1) Face page letter identifying applicant and a brief description of previous training in medical research, previous research interests, current position and future research interests. 2) NIH biosketch (sections B & C only). 3) Letters of support/reference from at least three current or previous mentors. A COMPLETE PROJECT PROPOSAL IS NOT REQUIRED UNTIL NOTIFIED.

Preliminary applications should be submitted via e-mail to Kate Slavashevich with Subject Line "Janssen Fellowship" to: kate.slavashevich@nyspi.columbia.edu

Funded post-doctoral positions are available in the lab of Dr. Michael Shen at the Herbert Irving Comprehensive Cancer Center to investigate the molecular mechanisms of genitourinary development and tumorigenesis. We are a dynamic, highly-collaborative group that investigates research topics at the interface of developmental, stem cell, and cancer biology (https://www.genetics.cumc.columbia.edu/research-labs/shen-lab). We are seeking highly-motivated applicants with a commitment to excellence for studies in the following areas:

1) Prostate organogenesis, stem/progenitor cells, and lineage specification – we use lineage-tracing and single-cell approaches to understand development, regeneration, and repair of the normal prostate. (Nature 461:495-500 (2009); Stem Cell Rep. 6:660-667 (2016); Development 144:1382-1398 (2017); Nat. Comm. 8:14662 (2017))

2) Prostate cancer initiation, progression, and castration-resistance – we use genetically-engineered mouse models and organoid culture approaches to elucidate cell types of origin as well as molecular mechanisms of prostate tumorigenesis (Nat. Cell Biol. 15:274-283 (2013); Cell Rep. 8:1339-1346 (2014); Nat. Cell Biol. 16:951-961 (2014); Cancer Discov. 7:736-749 (2017); eLife 7:e28768 (2018))

3) Molecular mechanisms of bladder tumorigenesis – we use human patient-derived organoid and xenograft models to analyze plasticity, clonal evolution, drug response, and metastasis in bladder cancer (Cell 173:515-528 (2018))

Successful candidates will have a Ph.D. degree with a strong background in stem cell biology, developmental biology, and/or cancer research. Expertise with mouse models, organoid culture, imaging, single-cell sequencing, genomic analyses, and/or bioinformatics would be advantageous.

To apply, please send a CV, detailed description of research experience and future interests, and the names of three references to Michael M. Shen, Ph.D. at mshen@columbia.edu

Postdoctoral Mouse Genetics:
Postdoctoral fellowship is available in the Department of Genetics & Development at Columbia University Medical Center in New York in the laboratory of Dr. Vincenzo A. Gennarino. Ideal candidates will be highly motivated scientists who will work in a top-quality, high-pressure biomedical science environment.

The primary responsibility will be to contribute to an active and innovative research program focused on the genetic alterations and RNA biology driving neurodegenerative and neurodevelopmental diseases. The ideal candidates must have demonstrated knowledge and experience with RNA biology, cell biology, protein biochemistry, general molecular biology, and transgenic/knockout mouse models. 

Applicants should send cover letter, curriculum vitae and names and addresses of three references by email to: Vincenzo A. Gennarino, Ph.D.: vag2138@cumc.columbia.edu

Postdoctoral Computational Biology:
Postdoctoral fellowship in computational biology/genomics is available in the Department of Genetics & Development at Columbia University Medical Center in New York in the laboratory of Dr. Vincenzo A. Gennarino. You will be a hard-working team player and a key person in the group and project essential for obtaining successful results. Ideal candidates will be highly motivated scientists who will work in a top-quality, high-pressure biomedical science environment. 

We aim to generate computational approaches for interrogating large-scale multi-omics datasets, patient transcriptome data, thereby combining evidence across molecular layers to dissect genetic and non-genetic risk factors for unknown neurological diseases. The Postdoc will be involved in a multidisciplinary project with the Department of Pediatrics and Neurology at Columbia University Medical Center. The successful applicant will hold a doctoral degree or equivalent qualification in computer science, statistics, mathematics, physics, and/or engineering, or a degree in biological science with demonstrated experience in computational and statistical work. 

Previous experience in developing and applying computational methods applied to large datasets is expected. Expertise in analysis and integration of multiomics data, statistical genetics, statistical interpretation and analysis of next-generation sequencing datasets is beneficial. 

Applicants should send curriculum vitae and names and addresses of three references by email to: Vincenzo A. Gennarino, Ph.D.: vag2138@cumc.columbia.edu