Fellowship in Mood, Anxiety and Related Disorders

This is a two- to three-year training fellowship in clinical and basic research on mood, anxiety and related disorders. It is supported by a NIMH grant, and offers didactic methodological and statistical training as well as a supervised research experience. There are eight positions in the fellowship. Two to three new fellows enter each year. See full details here

Eligibility

MD with completed psychiatric or neurological residency, or PhD

U.S. citizen or permanent resident

Contact

Steven P. Roose, MD, spr2@cumc.columbia.edu 

Deadline: November 30 (For receipt of fully completed applications)

[See Application]

Janssen Fellowship in Translational Neuroscience Research

The Paul Janssen Fellowship is awarded annually to an outstanding young physician-investigator (must have M.D. or Ph.D. degree) to conduct novel translational research in the field of neuroscience as it relates to psychiatric disease and medicine. The Paul Janssen Fellow will be assigned both a basic scientist mentor and a clinical investigator mentor from the faculty at Columbia University to serve as joint mentors. The fellow will take a basic observation made by the basic science mentor and apply it to the study of disease or treatment with the clinical research mentor. See full details here.

Funding

The award provides a stipend, commensurate with experience. The stipend provided may require supplemental funding by the mentors.

Length of Fellowship

For one year, and potentially renewable for a second year based on performance.

Eligibility

Candidates from the international neuroscience community, holding an M.D. or Ph.D. degree, and preferably having completed initial fellowship research training, are invited to apply. Fellows at Columbia University or the New York State Psychiatric Institute/RFMH are encouraged to submit applications. **Faculty are not eligible.

Application

Preliminary Application Process (by November 2019): The following should be provided in 12 point font (or larger) with a minimum of one-inch margins: 1) Face page letter identifying applicant and a brief description of previous training in medical research, previous research interests, current position and future research interests. 2) NIH biosketch (sections B & C only). 3) Letters of support/reference from at least three current or previous mentors. A COMPLETE PROJECT PROPOSAL IS NOT REQUIRED UNTIL NOTIFIED.

Preliminary applications should be submitted via e-mail to Kate Slavashevich with Subject Line "Janssen Fellowship" to: kate.slavashevich@nyspi.columbia.edu

Funded post-doctoral positions are available in the lab of Dr. Michael Shen at the Herbert Irving Comprehensive Cancer Center to investigate the molecular mechanisms of genitourinary development and tumorigenesis. We are a dynamic, highly-collaborative group that investigates research topics at the interface of developmental, stem cell, and cancer biology (https://www.genetics.cumc.columbia.edu/research-labs/shen-lab). We are seeking highly-motivated applicants with a commitment to excellence for studies in the following areas:

1) Prostate organogenesis, stem/progenitor cells, and lineage specification – we use lineage-tracing and single-cell approaches to understand development, regeneration, and repair of the normal prostate. (Nature 461:495-500 (2009); Stem Cell Rep. 6:660-667 (2016); Development 144:1382-1398 (2017); Nat. Comm. 8:14662 (2017))

2) Prostate cancer initiation, progression, and castration-resistance – we use genetically-engineered mouse models and organoid culture approaches to elucidate cell types of origin as well as molecular mechanisms of prostate tumorigenesis (Nat. Cell Biol. 15:274-283 (2013); Cell Rep. 8:1339-1346 (2014); Nat. Cell Biol. 16:951-961 (2014); Cancer Discov. 7:736-749 (2017); eLife 7:e28768 (2018))

3) Molecular mechanisms of bladder tumorigenesis – we use human patient-derived organoid and xenograft models to analyze plasticity, clonal evolution, drug response, and metastasis in bladder cancer (Cell 173:515-528 (2018))

Successful candidates will have a Ph.D. degree with a strong background in stem cell biology, developmental biology, and/or cancer research. Expertise with mouse models, organoid culture, imaging, single-cell sequencing, genomic analyses, and/or bioinformatics would be advantageous.

To apply, please send a CV, detailed description of research experience and future interests, and the names of three references to Michael M. Shen, Ph.D. at mshen@columbia.edu

Postdoctoral Mouse Genetics:
Postdoctoral fellowship is available in the Department of Genetics & Development at Columbia University Medical Center in New York in the laboratory of Dr. Vincenzo A. Gennarino. Ideal candidates will be highly motivated scientists who will work in a top-quality, high-pressure biomedical science environment.

The primary responsibility will be to contribute to an active and innovative research program focused on the genetic alterations and RNA biology driving neurodegenerative and neurodevelopmental diseases. The ideal candidates must have demonstrated knowledge and experience with RNA biology, cell biology, protein biochemistry, general molecular biology, and transgenic/knockout mouse models. 

Applicants should send cover letter, curriculum vitae and names and addresses of three references by email to: Vincenzo A. Gennarino, Ph.D.: vag2138@cumc.columbia.edu

Postdoctoral Computational Biology:
Postdoctoral fellowship in computational biology/genomics is available in the Department of Genetics & Development at Columbia University Medical Center in New York in the laboratory of Dr. Vincenzo A. Gennarino. You will be a hard-working team player and a key person in the group and project essential for obtaining successful results. Ideal candidates will be highly motivated scientists who will work in a top-quality, high-pressure biomedical science environment. 

We aim to generate computational approaches for interrogating large-scale multi-omics datasets, patient transcriptome data, thereby combining evidence across molecular layers to dissect genetic and non-genetic risk factors for unknown neurological diseases. The Postdoc will be involved in a multidisciplinary project with the Department of Pediatrics and Neurology at Columbia University Medical Center. The successful applicant will hold a doctoral degree or equivalent qualification in computer science, statistics, mathematics, physics, and/or engineering, or a degree in biological science with demonstrated experience in computational and statistical work. 

Previous experience in developing and applying computational methods applied to large datasets is expected. Expertise in analysis and integration of multiomics data, statistical genetics, statistical interpretation and analysis of next-generation sequencing datasets is beneficial. 

Applicants should send curriculum vitae and names and addresses of three references by email to: Vincenzo A. Gennarino, Ph.D.: vag2138@cumc.columbia.edu

postdoctoral researchers to study the neurodevelopmental mechanisms of stress-induced psychiatric disorders.

Our laboratory is interested the neurodevelopmental mechanisms underlying abnormalities in cognitive and emotional behaviors that contribute to psychiatric disorders. In particular, we are using transgenic mouse models to investigate how brain development is influenced by stress, especially during early life, and how differences in the development of the hippocampus can influence cognitive and emotional behavior in adulthood. We are using a variety of in vivo techniques to visualize and regulate hippocampal stem cell development in the brain, including in vivo Ca2+ imaging of newborn neurons in freely moving mice, as well as optogenetic- and chemogenetic techniques (DREADDs) to stimulate or inhibit newborn hippocampal neurons and to determine their functional effects on cognition and anxiety. We are combining these techniques with our established models of psychological stress and early life adversity to investigate how stress during different stages of development impairs stem cell proliferation, differentiation, maturation, and the functional integration of neurons that develop from these stem cells.

Interested applicants should contact Dr. Christoph Anacker (ca2635@cumc.columbia.edu.)

The Claudia Doege lab at Columbia University Irving Medical Center in New York City is seeking a highly motivated Postdoctoral Research Scientist with expertise in stem cell biology and/or neurobiology to study the molecular genetics of Prader-Willi syndrome. This work will involve creation and molecular characterization of mutation-specific human stem cell-derived hypothalamic organoids.  

Qualifications: 

1. Experience and knowledge in human stem cell biology and/or neurobiology.
2. Ability to work independently and as part of a team.
3. Excellent written and oral communication skills in English.
4. Record of productive research. 
5. Education: Ph.D. and/or M.D. 

Salary is competitive and will be based on qualifications.

Applicants should send curriculum vitae, statement of interest, and contact information for three references to:

Claudia Doege, cad2114@cumc.columbia.edu