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Joint Development and Regeneration
Osteoarthritis – the progressive deterioration of joints due to injury and/or wear-and-tear – is the leading cause of disability in the United States. Unfortunately, the cartilage and ligaments of mammalian joints show little ability to regenerate following damage. We have developed novel genetic and joint injury models in the highly regenerative zebrafish to uncover endogenous stem cell populations within adult joints. Studies in our laboratory use genetic, cellular, and molecular approaches in zebrafish to understand how joint cells are activated following injury and to uncover the regulatory framework of cell fate decisions during the differentiation of progenitor cells into articular cartilage and ligaments. Our long-term goal is to translate these findings to activate stem cells for joint repair and develop regenerative treatments to restore function in patients suffering from osteoarthritis or traumatic joint injury.
Programmed conversion of hypertrophic chondrocytes into osteoblasts and marrow adipocytes within zebrafish bones. Giovannone D, Paul S, Schindler S, Arata C, Farmer DT, Patel P, Smeeton J, Crump JG.Giovannone D, et al. Elife. 2019 Feb 20; 8:e42736. doi: 10.7554/eLife.42736.Elife. 2019. PMID: 30785394 Free PMC article.
De novo variants in GREB1L are associated with non-syndromic inner ear malformations and deafness. Schrauwen I, Kari E, Mattox J, Llaci L, Smeeton J, Naymik M, Raible DW, Knowles JA, Crump JG, Huentelman MJ, Friedman RA.Schrauwen I, et al. Hum Genet. 2018 Jul; 137(6-7):459-470. doi: 10.1007/s00439-018-1898-8. Epub 2018 Jun 28. Hum Genet. 2018.PMID: 29955957 Free PMC article.
Building and maintaining joints by exquisite local control of cell fate. Smeeton J, Askary A, Crump JG. Smeeton J, et al. Wiley Interdiscip Rev Dev Biol. 2017 Jan; 6(1):10.1002/wdev.245. doi: 10.1002/wdev.245. Epub 2016 Sep 1. Wiley Interdiscip Rev Dev Biol. 2017. PMID: 27581688 Free PMC article. Review.
Ancient origin of lubricated joints in bony vertebrates. Askary A, Smeeton J, Paul S, Schindler S, Braasch I, Ellis NA, Postlethwait J, Miller CT, Crump JG. Askary A, et al. Elife. 2016 Jul 19; 5:e16415. doi: 10.7554/eLife.16415. Elife. 2016.PMID: 2743466 6Free PMC article.
Integrin-linked Kinase Controls Renal Branching Morphogenesis via Dual Specificity Phosphatase 8. Smeeton J, Dhir P, Hu D, Feeney MM, Chen L, Rosenblum ND.Smeeton J, et al. J Am Soc Nephrol. 2016 May; 27(5):1465-77. doi: 10.1681/ASN.2015020139. Epub 2015 Sep 25. J Am Soc Nephrol. 2016.P MID: 26407593 Free PMC article.
Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development. Smeeton J, Zhang X, Bulus N, Mernaugh G, Lange A, Karner CM, Carroll TJ, Fässler R, Pozzi A, Rosenblum ND, Zent R.Smeeton J, et al. Development. 2010 Oct; 137(19):3233-43. doi: 10.1242/dev.052845.Development. 2010.P MID: 20823064 Free PMC article.
Genetics of renal hypoplasia: insights into the mechanisms controlling nephron endowment. Cain JE, Di Giovanni V, Smeeton J, Rosenblum ND.Cain JE, et al. Pediatr Res. 2010 Aug; 68(2):91-8. doi: 10.1203/PDR.0b013e3181e35a88. Pediatr Res. 2010. PMID: 20421843 Review.