Location and Contact Information
The Yazawa laboratory uses interdisciplinary approaches including stem cell biology, electrophysiology, pharmacology, genetics, development, optics, and bioengineering to uncover the molecular mechanism underlying human genetic diseases and to develop new therapies. Our team uses human pluripotent stem cell and rodent models to investigate the molecular and cellular mechanisms underlying genetic cardiac diseases including long QT syndrome and cardiomyopathy.
In particular, our team has focused on investigating rare children’s lethal diseases in order to identify new therapeutic targets since pharmaceutical companies have not targeted such rare diseases due to their marketing concern.
To understand further calcium handling in excitable tissues such as hearts, muscles, brains, and pancreas, we also work on identifying novel molecules that are essential for the tissue development and function and also could be new therapeutic target for human diseases.
Former Lab Members
Daniel W. Awari (2013-2014)
Elizabeth Han (2013-2015)
Yehuda Isseroff (2013)
Fuun Kawano, PhD
Yumeko Kawano (2015-2017)
Seonhye Emily Park (2014-2016)
Steven H. Su (2015)
Eugenia Uche-Anya (2014)
Shunnosuke Ueno (2015-2017)
Yoko Yabe (2013-2015)
Song L, Park SE, Isseroff Y, Morikawa K, Yazawa M. Inhibition of CDK5 alleviates the cardiac phenotypes in Timothy syndrome. Stem Cell Reports. July 11; 9(1)50-57. (2017). PMID: 28648896
Sun, N.*, Yazawa, M.*, Liu J, Han L, Sanchez-Freire V, Abilez OJ, Navarrete EG, Hu S, Wang L, Lee A, Pavlovic A, Lin S,z Chen R, Hajjar RJ, Snyder MP, Dolmetsch RE, Butte MJ, Ashley EA, Longaker MT, Robbins RC, Wu JC. Patient-Specific Induced Pluripotent Stem Cell as A Model for Familial Dilated Cardiomyopathy. Science Translational Medicine. 4 (130), 130ra47 (2012). PMID: 22517884 *These authors contributed equally to this work.
Yazawa, M., Hsueh, B., Jia, X, Pasca, A.M., Bernstein, J.A., Hallmayer, J. and Dolmetsch, R.E. Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome. Nature 471, 230-234 (2011). PMID: 21307850
Yazawa, M., Ferrante, C., Feng, J., Mio, K., Ogura, T., Zhang, M., Lin, PH., Pan, Z., Komazaki, S., Kato, K., Nishi, M., Zhao,X., Weisleder, N., Sato, C., Ma, J. and Takeshima, H. TRIC channels are essential for Ca2+ handling in intracellular stores. Nature 448, 78-82 (2007). PMID: 17611541
Kawano F. Shi F and Yazawa M Optogenetics: Switching with red and blue. Nat. Chem. Biol. May 17;16(6):573-574. (2017). PMID: 28514429
Kawano F. Okazaki R, Yazawa M and Sato M. A photoactivatable Cre/loxP recombination system for optogenetic genome engineering. Nat. Chem. Biol. Dec;12(12):1059-1064 Epub 2016 Oct. 10. (2016). PMID: 27723747
Yazawa, M., Sadaghiani, A.M., Hsueh, B. & Dolmetsch, R.E. Induction of protein-protein interactions in live cells using light. Nature Biotechnology. 27, 941-945 (2009). PMID: 19801976