Kimara L. Targoff, MD

Board Certifications: 
Pediatric Cardiology
Treats Children
Profile Headshot

Overview

Areas of Expertise / Conditions Treated

Research Studies

Academic Appointments

  • Assistant Professor of Pediatrics at CUMC

Kimara L. Targoff, MD, is interested in the identification and characterization of genes that are essential for key developmental processes in cardiac morphogenesis. She works clinically as a Pediatric Cardiologist at NewYork-Presbyterian Morgan Stanley Children's Hospital. Simultaneously, Dr. Targoff studies the genetic mechanisms regulating heart development in zebrafish. Her laboratory's research is focused on the role of nkx genes, cardiac-specific homeodomain transcription factors, in establishing and maintaining cardiomyocyte identity.

Hospital Affiliations

  • NewYork-Presbyterian/Morgan Stanley Children's Hospital
  • NewYork-Presbyterian/Columbia

Gender

  • Female

Location(s)

CUMC/NewYork-Presbyterian Morgan Stanley Children's Hospital
3959 Broadway
New York, NY 10032
Primary

Insurance Accepted

Aetna

  • EPO
  • HMO
  • Medicare Managed Care
  • NY Signature
  • POS
  • PPO
  • Signature Administrators
  • Student Health

Affinity

  • Essential Plan
  • Medicaid Managed Care
  • Medicare Managed Care

Amida Care

  • Special Needs Plan

Cigna

  • EPO
  • Great West
  • HMO
  • POS
  • PPO

Emblem/GHI

  • HMO
  • Medicare Managed Care
  • PPO

Emblem/HIP

  • ConnectiCare
  • EPO
  • Essential Plan
  • HMO
  • Medicaid Managed Care
  • Medicare Managed Care
  • POS
  • PPO
  • Select Care (Exchange)
  • Vytra

Empire Blue Cross Blue Shield

  • Blue Priority
  • EPO
  • HMO
  • Medicare (Mediblue)
  • NYP Employee Plan
  • Pathway (Exchange)
  • POS
  • PPO

Empire Blue Cross Blue Shield HealthPlus

  • Child/Family Health Plus
  • Essential Plan
  • Medicaid Managed Care

Fidelis Care

  • Child/Family Health Plus
  • Medicaid Managed Care
  • Medicare Managed Care

Healthfirst

  • Child/Family Health Plus
  • Medicaid Managed Care
  • Medicare Managed Care

Local 1199

  • Local 1199

MagnaCare

  • MagnaCare

Multiplan

  • Multiplan

Oxford Health Plans

  • Freedom
  • Liberty
  • Medicare Managed Care

UnitedHealthcare

  • Columbia University Employee Plan
  • Compass (Exchange)
  • EPO
  • Essential Plan
  • HMO
  • Medicaid (Community Plan)
  • Medicare Managed Care
  • POS
  • PPO

VNSNY CHOICE

  • Medicare Managed Care
  • SelectHealth

WellCare

  • Medicaid Managed Care
  • Medicare Managed Care

*Please contact the provider’s office directly to verify that your particular insurance is accepted.

Credentials & Experience

Education & Training

  • Yale University School of Medicine
  • Internship: NewYork-Presbyterian Hospital/Columbia University Medical Center
  • Residency: NewYork-Presbyterian Hospital/Columbia University Medical Center
  • Fellowship: NewYork-Presbyterian Hospital/Columbia University Medical Center

Board Certifications

  • Pediatric Cardiology

Honors & Awards

2014                            Colin Molloy Research Award, Colin’s Kids Organization

2014                            First Babies Heart Fund Research Award, Division of Pediatric Cardiology, Columbia University

2005                            The Welton M. Gersony Research Award, Division of Pediatric Cardiology, Columbia University

2005                            Best Basic Research Abstract Award,Pediatric Research Symposium, Columbia University

2004                            American Heart Association Women in Cardiology Travel Grant

Research

Dr. Targoff’s research interests focus on understanding cardiac morphogenesis:  a carefully orchestrated process representing the first organogenesis milestone in developing vertebrate embryos.  Establishment of specific molecular and cellular characteristics of the two major cardiac chambers, the ventricle and the atrium, is crucial to formation of a functional heart.  Despite the importance of maintaining unique features in chamber-specific cardiomyocytes, the regulatory mechanisms guiding these processes are yet to be uncovered.  The strong association of NKX2-5 with human congenital heart disease in both chambers and our studies revealing the differential effects of nkx genes on ventricular and atrial cell number in zebrafish prompted our interest in the role of Nkx genes in chamber identity.  By exploiting the experimental benefits of the zebrafish model, the Targoff Lab has shown that ventricular cardiomyocytes transdifferentiate into atrial cardiomyocytes in the absence of nkx gene function, highlighting the malleable nature of differentiated myocardium.  These newly revealed functions of Nkx genes in preserving chamber-specific traits have the potential to elucidate the molecular, cellular, and electrophysiological phenotypes in models of Nkx2-5 deficiency.

Research Interests

  • Cardiovascular Development
  • Cardiovascular Regeneration
  • Cardiac Stem Cell Biology
  • Cardiac Genetics

Grants

MECHANISMS OF SECOND HEART FIELD DEVELOPMENT REGULATED BY NKX GENES (Federal Gov)

Jan 1 2017 - Dec 31 2021

MECHANISMS OF SECOND HEART FIELD DEVELOPMENT REGULATED BY CRIP GENES DOWNSTREAM OF NKX FACTORS (Private)

Jan 1 2018 - Dec 31 2018

MECHANISMS OF CARDIOMYOCYTE RENEWAL REGULATED BY NKX2.5 (Private)

Nov 1 2017 - Oct 31 2018

REGULATION OF CARDIAC MORPHOGENESIS BY NKX GENES IN THE ZEBR AFISH EMBRYO (Federal Gov)

Jul 1 2007 - Apr 30 2012

Selected Publications

Harrington, J.K., Sorabella, R., Tercek, A., Isler, J.R., Targoff, K.L.  Nkx2.5 is Essential to Establish Normal Heart Rate Variability in the Zebrafish Embryo.  Am J Physiol Regulatory Integrative Comparative Physiology, June 14th, 2017.  (PMID: 28615160)

Pradhan, A., Zeng, X.X., Sidhwani, P., Marques, S. George, V., Targoff, K.L., Chi, N., Yelon, D.  FGF signaling enforces cardiac chamber identity in the developing ventricle. Development, April 1st, 2017; 144(7):  1328-1338.  (PMID: 28232600)

Iklé, J.M., Tavares, A.L., King, M., Ding, H., Colombo, S., Firulli, B.A., Firulli, A.B., Targoff K.L., Yelon, D., Clouthier, D.E.  Nkx2.5 regulates endothelin converting enzyme-1 during pharyngeal arch patterning.  Genesis, Jan. 20th, 2017.  (PMID:  28109039)

Nagelberg, D., Wang, J., Su, R., Torres-Vázquez, J., Targoff, K.L., Poss, K.D., Knaut, H.  Origin, Specification, and Plasticity of the Great Vessels of the Heart.  Current Biology, 25(16):  2099-110, 2015.  (PMID:  26255850)

George, V., Colombo, S., Targoff, K.L.*  An early requirement for nkx2.5 ensures the first and second heart field ventricular identity and cardiac function into adulthood.  Developmental Biology, 400(1): 10-22, 2015.  (PMID:  25536398)

Wei, L., Shen, Y., Xu, F., Hu, F., Harrington, J.K., Targoff, K.L., Min, W.  Imaging Complex Protein Metabolism in Live Organisms by Stimulated Raman Scattering Microscopy with Isotope Labeling.  ACS Chemical Biology, 10(3): 901-8, 2015.  (PMID:  25560305)

Targoff, K.L., Colombo, S., George, V., Schell, T., Kim, S.-H., Solnica-Krezel, L., Yelon, D.  Nkx genes are essential for maintenance of ventricular identity.  Development, 140(20):  4203-13, 2013.  (PMID:  24026123)   

Bigelow, A.W., Ponnaiya, B., Targoff, K.L., Brenner, D.  UV microspot irradiator at Columbia University.  Radiation and Environmental Biophysics, 52(3):  411-7, 2013.  (PMID:  23708525)

Targoff, K.L., Schell, T., Yelon, D. Nkx genes regulate heart tube extension in zebrafish and exert differential effects on ventricular and atrial cell number.  Developmental Biology 322(2):  314-321, 2008.  (PMID:  18718462)

Chen, J.M., Mosca, R.S., Altmann, K., Printz, B.F., Targoff, K., Mazzeo, P.A., Quaegebeur, J.M.  Early and medium-term results for repair of Ebstein anomaly.  J Thorac Cardiovasc Surg 127(4): 990-8, 2004.  (PMID:  15052195)

Mazure, C.M., Leibowitz, K.J., Bowers, Jr., M.B.   Drug-responsive mania in a man with a brain tumor.  The Journal of Neuropsychiatry and Clinical Neurosciences.  11(1):  114-5, Winter 1999.  (PMID:  9990567)

Tempel, D., Leibowitz, K.J., Leibowitz, S.F.  Effects of PVN galanin on macronutrient selection.  Peptides 9(2):  309-14, 1988.  (PMID:  2453854)