Bin Xu, PhD

Profile Headshot

Overview

Academic Appointments

  • Assistant Professor of Neurobiology (in Psychiatry) at CUMC

Research Interests: My main research interests lie in two directions: 1). Identifying genetic mutations with large effects through high throughput deep sequencing. 2). Determining the impact of rare genetic mutations in pathophysiology of major neuropsychiatric disorders using human induced pluripotent stem cells (iPSC) based disease model. We have developed methods for mimicing the developing human brain, named cerebral organoids, to investigate how rare genetic mutations [i.e. 22q11 microdeletion syndrome (Xu et al Nature Genetics 2012); SETD1A (Takata et al Neuron); KMT2B (Meyer et al Nature Genetic 2017)] lead to deficits in neural cells derived from patients with neuropsychiatric disorders, such as autism or schizophrenia, and what should be therapeutically targeted in these conditions.

Postdoc Position: If you are interested in our research and highly motivated to work with us, please email me at bx2105 at cumc.columbia.edu with a cover letter describing your previous working experience and career goals and your CV.

Languages

  • Chinese

Credentials & Experience

Education & Training

  • BS, Genetics, Wuhan University (China)
  • MS, Biochemistry and Molecular Biology, Beijing Medical University (China)
  • PhD, Human Genetics, Rutgers-The State University of New Jersey

Research

Research Interests

  • neurobiology of neurodevelopmental diseases
  • human genetics of neuropsychiatric disorders
  • human stem cell based disease modeling

Grants

THE EPIGENETIC MECHANISMS OF HIGH-GRADE PEDIA (Federal Gov)

Jun 15 2017 - May 31 2022

DECIPHERING THE ROLE OF HISTONE METHYLTRANSFE (Federal Gov)

Mar 1 2017 - Feb 28 2022

INTEGRATIVE METHODS FOR THE IDENTIFICATION OF CAUSAL VARIANTS IN MENTAL DISORDER (Federal Gov)

Apr 14 2016 - Jan 31 2020

FUNCTIONAL ANALYSIS FOR NHGRI UNDIAGNOSED DISEASE PATIENTS (Federal Gov)

Sep 1 2015 - Aug 31 2018

ATTAINING AND MAINTAINING WELLNESS IN OCD (Federal Gov)

Aug 1 2012 - Jul 31 2018

FUNCTIONAL ANALYSIS OF THE 22Q11.2 SCHIZOPHRENIA SUSCEPTIBILITY GENES (Federal Gov)

Dec 1 2002 - Jun 30 2018

ATTAINING AND MAINTAINING WELLNESS IN OCD (Federal Gov)

Aug 1 2012 - Jul 31 2017

ATTAINING AND MAINTAINING WELLNESS IN OCD (Federal Gov)

Aug 1 2012 - Jul 31 2016

MAPPING GENES FOR SCHIZOPHRENIA IN A FOUNDER POPULATION (Federal Gov)

Apr 10 2010 - Jun 30 2016

ATTAINING AND MAINTAINING WELLNESS IN OCD (Federal Gov)

Aug 1 2012 - Apr 30 2016

EVALUATING THE FUNCTIONAL IMPACT OF EPIGENETIC CONTROL-RELATED GENES MUTATED IN BOTH SCHIZOPHRENIA AND AUTISM (Private)

Jan 15 2014 - Jan 14 2016

ATTAINING AND MAINTAINING WELLNESS IN OCD (Federal Gov)

Aug 1 2012 - Apr 30 2015

ATTAINING AND MAINTAINING WELLNESS IN OCD (Federal Gov)

Aug 1 2012 - Jul 31 2013

IPS CELL-DERIVED NEURONS CARRYING AN ALLELIC SERIES OF CNTNA P2 STRUCTURAL MUTATIONS (Federal Gov)

Sep 30 2009 - Aug 31 2012

UNDERSTANDING THE GENOMIC RISK ARCHITECTURE OF SCHIZOPHRENIA USING GENE EXPRESSION ANALYSIS IN MODEL SYSTEMS (Federal Gov)

Sep 30 2009 - Aug 31 2012

ELUCIDATING THE EFFECT OF DISC1 DEFICIENCY ON NEURODEVELOPME NT AND COGNITION (Federal Gov)

Jul 15 2007 - Mar 31 2012

A GENETIC MOUSE MODEL OF THE 22Q11 DELETION SYNDROME IMPLICA TES MIRNA BIOGENESIS IN THE COGNITIVE DE (Private)

Jun 1 2008 - May 31 2011

THE CONTRIBUTION OF ABNORMAL MICRORNA BIOGENESIS TO THE PSYC HIATRIC SYMPTOMS OF 2Q11 DELETION SYNDRO (Private)

Jul 1 2008 - Jun 30 2010

Selected Publications

Takata A, Ionita-Laza I, Gogos JA, Xu B, Karayiorgou M. De Novo Synonymous Mutations in Regulatory Elements Contribute to the Genetic Etiology of Autism and Schizophrenia. Neuron. 2016 Mar 2;89(5):940-7. doi: 10.1016/j.neuron.2016.02.024. PubMed PMID: 26938441; PubMed Central PMCID: PMC4793939. 

Ionita-Laza I, McCallum K, Xu B, Buxbaum JD. A spectral approach integrating functional genomic annotations for coding and noncoding variants. Nat Genet. 2016 Feb;48(2):214-20. doi: 10.1038/ng.3477. Epub 2016 Jan 4. PubMed PMID: 26727659; PubMed Central PMCID: PMC4731313. 
Takata A, Xu B, Ionita-Laza I, Roos JL, Gogos JA, Karayiorgou M. Loss-of-function variants in schizophrenia risk and SETD1A as a candidate susceptibility gene. Neuron. 2014 May 21;82(4):773-80. doi: 10.1016/j.neuron.2014.04.043. PubMed PMID: 24853937; PubMed Central PMCID: PMC4387883. 

Ionita-Laza I, Xu B, Makarov V, Buxbaum JD, Roos JL, Gogos JA, Karayiorgou M.  Scan statistic-based analysis of exome sequencing data identifies FAN1 at 15q13.3 as a susceptibility gene for schizophrenia and autism. Proc Natl Acad Sci U S A.  2014 Jan 7;111(1):343-8. doi: 10.1073/pnas.1309475110. Epub 2013 Dec 16. PubMed PMID: 24344280; PubMed Central PMCID: PMC3890869. 
Fénelon K, Xu B, Lai CS, Mukai J, Markx S, Stark KL, Hsu PK, Gan WB, Fischbach GD, MacDermott AB, Karayiorgou M, Gogos JA. The pattern of cortical dysfunction in a mouse model of a schizophrenia-related microdeletion. J Neurosci. 2013 Sep 11;33(37):14825-39. doi: 10.1523/JNEUROSCI.1611-13.2013. PubMed PMID: 24027283; PubMed Central PMCID: PMC3771024. 

Xu B, Hsu PK, Stark KL, Karayiorgou M, Gogos JA. Derepression of a neuronal inhibitor due to miRNA dysregulation in a schizophrenia-related microdeletion. Cell. 2013 Jan 17;152(1-2):262-75. doi: 10.1016/j.cell.2012.11.052. PubMed PMID:  23332760; PubMed Central PMCID: PMC3556818. 
Gilman SR, Chang J, Xu B, Bawa TS, Gogos JA, Karayiorgou M, Vitkup D. Diverse types of genetic variation converge on functional gene networks involved in schizophrenia. Nat Neurosci. 2012 Dec;15(12):1723-8. doi: 10.1038/nn.3261. Epub 2012 Nov 11. PubMed PMID: 23143521; PubMed Central PMCID: PMC3689007. 

Xu B, Ionita-Laza I, Roos JL, Boone B, Woodrick S, Sun Y, Levy S, Gogos JA, Karayiorgou M. De novo gene mutations highlight patterns of genetic and neural complexity in schizophrenia. Nat Genet. 2012 Dec;44(12):1365-9. doi: 10.1038/ng.2446. Epub 2012 Oct 3. PubMed PMID: 23042115; PubMed Central PMCID: PMC3556813. 

Xu B, Hsu PK, Karayiorgou M, Gogos JA. MicroRNA dysregulation in neuropsychiatric disorders and cognitive dysfunction. Neurobiol Dis. 2012 May;46(2):291-301. doi: 10.1016/j.nbd.2012.02.016. Epub 2012 Mar 3. Review. PubMed PMID: 22406400; PubMed Central PMCID: PMC3329786. 

Xu B, Roos JL, Dexheimer P, Boone B, Plummer B, Levy S, Gogos JA, Karayiorgou M. Exome sequencing supports a de novo mutational paradigm for schizophrenia. Nat Genet. 2011 Aug 7;43(9):864-8. doi: 10.1038/ng.902. PubMed PMID: 21822266; PubMed Central PMCID: PMC3196550. 

Xu B, Karayiorgou M, Gogos JA. MicroRNAs in psychiatric and neurodevelopmental disorders. Brain Res. 2010 Jun 18;1338:78-88. doi: 10.1016/j.brainres.2010.03.109. Epub 2010 Apr 10. Review. PubMed PMID: 20388499;  PubMed Central PMCID: PMC2883644. 
Xu B, Woodroffe A, Rodriguez-Murillo L, Roos JL, van Rensburg EJ, Abecasis GR, Gogos JA, Karayiorgou M. Elucidating the genetic architecture of familial schizophrenia using rare copy number variant and linkage scans. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16746-51. doi: 10.1073/pnas.0908584106. Epub 2009  Sep 11. PubMed PMID: 19805367; PubMed Central PMCID: PMC2757863. 

Xu B, Roos JL, Levy S, van Rensburg EJ, Gogos JA, Karayiorgou M. Strong association of de novo copy number mutations with sporadic schizophrenia. Nat Genet. 2008 Jul;40(7):880-5. doi: 10.1038/ng.162. Epub 2008 May 30. PubMed PMID:  18511947. 

Stark KL, Xu B, Bagchi A, Lai WS, Liu H, Hsu R, Wan X, Pavlidis P, Mills AA,  Karayiorgou M, Gogos JA. Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat Genet. 2008 Jun;40(6):751-60. doi: 10.1038/ng.138. Epub 2008 May 11. PubMed PMID: 18469815.