Barbara Corneo, PhD

Profile Headshot

Overview

Barbara manages the daily activity of the Columbia Stem Cell Core Facility, bringing her knowledge in stem cell research and enthusiasm for collaborating and teaching to serve the Columbia Stem Cell Community as well as external users. Barbara grew up in Italy and got a PhD in Immunology in Paris, France, working on severe combined immunodeficiency and V(D)J recombination. She then moved to the United States where she continued working on the effects that mutations in the Rag1 & 2 genes cause on the immune system. Barbara then joined Dr. Gordon Keller lab in Mount Sinai, where she learned the basis of hESC biology and worked on endoderm differentiation and specification toward hepatic and pancreatic progenitors. She then joined the Neural Stem Cell Institute, directed by Dr. Sally Temple, to learn more about the nervous system. She worked on iPSC derivation from human ocular tissues and differentiation of hESC and hiPSC into retinal pigment epithelium (RPE). Barbara now directs the Columbia Stem Cell Core Facility, to provide support and to offer her expertise and help to any user interested in learning more about adult stem cells, embryonic stem cells, induced pluripotent stem cells and their differentiated progenies.

Academic Appointments

  • Associate Professor of Rehabilitation and Regenerative Medicine at CUMC

Administrative Titles

  • Director, Columbia Stem Cell Core Facility

Languages

  • French
  • Italian

Gender

  • Female

Credentials & Experience

Education & Training

  • PhD, Immunology, University of Paris VI Rene Descartes

Research

Don't stop 'til you get enough

The Stem Cell Core Facility is a multi-center facility at Columbia University Medical Center, created to help users take advantage of up-to-date resources in the stem cell field in a timely and cost-efficient way.

The Columbia Stem Cell Core Facility has two primary aims:

To give our users access to quality-controlled pluripotent stem cells and stem cell-derivatives prepared using standardized approaches

To offer genome editing services for the generation of custom-designed cell lines

We are connected to Stem Cell COREdinates, a consortium of pluripotent stem cells-focused core facilities, which allows us to take advantage of the sharing of the most updated and efficient protocols, expertise, and reagents.

Research Interests

  • Stem Cells, Disease models

Selected Publications

1) Patel A, Diaz AG, Moore JC,Sirabella D & Corneo B.Establishment and characterization of two iPSC lines derived from healthy controls.Stem Cell Research, 2020 Jul 25;47:101926.

2) Garcia-Diaz A., Efe G.,Kabra K,Patel A,Lowry E.R.,Shneider N.,Corneo B.,Wichterle H.Standardized reporter systems for purification and imaging of human pluripotent stem cell-derived motor neurons and other cholinergic cells.Neuroscience, 2020 Jun 30:S0306-4522(20)30404-8.

3) Liu J, Taylor R.L., Baines R.A., Swanton L., Freeman S.,Corneo B., Patel A.,Marmorstein A., Knudsen T., Black G.C., Manson F.Small molecules restore bestrophin-1 expression and function of both dominant and recessive bestrophinopathies in patient-derived RPE.IOVS.2020 May 11;61(5):28. PMID:32421148

4) Riera M,Patel A, Burés-Jelstrup A, Corcostegui B, Chang S, Pomares E,Corneo B,Sparrow JR.Generation of two iPS cell lines (FRIMOi003-A and FRIMOi004-A) derived from Stargardt patients carrying ABCA4 compound heterozygous mutations.Stem Cell Res.2019 Apr;36:101389. PMID: 30798147

5) Riera M,Patel A,Corcostegui B, Chang S, Sparrow JR, Pomares E,Corneo B.Establishment and characterization of an iPSC line (FRIMOi001-A) derived from a retinitis pigmentosa patient carrying PDE6A mutations.Stem Cell Res.2019; 35:101385. PMID: 30685614

6) Riera M,Patel A,Corcostegui B, Chang S,Corneo B, Sparrow JR, Pomares E.Generation of an induced pluripotent stem cell line (FRIMOi002-A) from a retinitis pigmentosa patient carrying compound heterozygous mutations in USH2A gene.Stem Cell Res. 2019; 35:101386. PMID: 30685615

7) Baulier E,Garcia Diaz A, Corneo B,Farber DB.Generation of a human Ocular Albinism type 1 iPSC line, SEIi001-A, with a mutation in GPR143.Stem Cell Res. 2018; 33:274-277. PMID: 30513407

8) Di Baldassarre A, D'Amico MA, Izzicupo P, Gaggi G, Guarnieri S, Mariggiò MA, Antonucci I,Corneo B, Sirabella D,Stuppia L, Ghinassi B.Cardiomyocytes Derived from Human CardiopoieticAmniotic Fluids.Scientific reports.2018 Aug 13;8(1):12028. doi: 10.1038/s41598-018-30537-z. PMID: 30104705. PMCID: PMC6089907.

9) Saini JS, Corneo B, Miller JD, Kiehl TR, Wang Q, Boles NC, Blenkinsop TA, Stern JH, Temple S. Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration. Cell stem cell. 2017; 20(5):635-647.e7. NIHMSID: NIHMS845902 PubMed [journal] PMID: 28132833, PMCID: PMC5419856

10) Miyagishima KJ*, Wan Q*, Corneo B*, Sharma R, Lotfi MR, Boles NC, Hua F, Maminishkis A, Zhang C, Blenkinsop T, Khristov V, Jha BS, Memon OS, D'Souza S, Temple S, Miller SS, Bharti K. In Pursuit of Authenticity: Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Clinical Applications. Stem cells translational medicine. 2016; 5(11):1562-1574. PubMed [journal] PMID: 27400791, PMCID: PMC5070511. *=co-first authors

11) Maruotti J, Sripathi SR, Bharti K, Fuller J, Wahlin KJ, Ranganathan V, Sluch VM, Berlinicke CA, Davis J, Kim C, Zhao L, Wan J, Qian J, Corneo B, Temple S, Dubey R, Olenyuk BZ, Bhutto I, Lutty GA, Zack DJ. Small-molecule-directed, efficient generation of retinal pigment epithelium from human pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America. 2015; 112(35):10950-5. PubMed [journal] PMID: 26269569, PMCID: PMC4568212