Here, we evaluate repair outcomes of a Cas9-induced double-strand break (DSB) introduced on the paternal chromosome at the EYS locus, which carries a frameshift mutation causing blindness.
In addition to known ectodermal contributions, we use lineage tracing and time-lapse imaging in zebrafish to identify an endodermal contribution to the ADH.
The Stem Cell Core Facility is one of the two core facilities of the Columbia Stem Cell Initiative (CSCI), the major stem cell program at the Columbia University Irving Medical Center.
This study demonstrates the feasibility of TMJ regeneration using anatomically precise, autologous, living cartilage-bone grafts for functional, personalized total joint replacement.
The link between cholesterol homeostasis and cleavage of the amyloid precursor protein, and how this relationship relates to Alzheimer's disease pathogenesis, is still unknown.
We report a cause of NKD resulting from compound heterozygous mutations in minichromosomal maintenance complex member 10 that impaired NK cell maturation in a child with fatal susceptibility to CMV.