Piero Dalerba, MD

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Overview

Email: pdd2109@cumc.columbia.edu

Academic Appointments

  • Assistant Professor of Pathology & Cell Biology

Languages

  • English
  • Italian

Credentials & Experience

Education & Training

  • MD, 1995 University of Milan (Italy)

Honors & Awards

  • 2019 - VELOCITY Fellow Grant Award - Columbia University Irving Medical Center (CUIMC)
  • 2018 - Young Investigator Grant (YIG) - Breast Cancer Alliance (BCA)
  • 2018 - “Kara Gelb” Memorial Grant - Adenoid Cystic Carcinoma Research Foundation (ACCRF)
  • 2017 - Schaefer Research Scholar - Columbia University Medical Center (CUMC)
  • 2016 - Runyon-Rachleff Innovation Award - Damon Runyon Cancer Research Foundation
  • 2012 - NCCN Young Investigator Award - National Comprehensive Cancer Network (NCCN)
  • 2012 - Siebel Scholars Program - Siebel Stem Cell Institute and The Thomas and Stacey Siebel Foundation
  • 2011 - BD Biosciences Stem Cell Research Grant - BD Biosciences
  • 2006 - CIRM Training Grant - California Institute for Regenerative Medicine (CIRM)
  • 2004 - FIRC “Leonino Fontana e Maria Lionello” Fellowship - Italian Foundation for Cancer Research (FIRC)
  • 2002 - 9th International PBI “Valentina Lana” Research Prize in Molecular Immunology - Italian Society for Immunology, Clinical Immunology and Allergology (SIICA)
  • 2001 - FIRC Research Fellowship - Italian Foundation for Cancer Research (FIRC)
  • 1996 - MURST Clinical Fellowship - Italian Ministry for Scientific and Technological Research (MURST)

Research

Our guiding principle is:

"Considerate la vostra semenza,
nati non foste a viver come bruti,
ma per seguir virtute e canoscenza."
- Dante, Inferno, Canto XXVI, 118-120

The two major research interests of our laboratory are:

a) Discovery of biomarkers that are predictive of tumor response to anti-neoplastic drugs, in order to improve therapeutic guidelines and decision-making algorithms for cancer patients (with a special focus on colon, breast and salivary gland malignancies);

b) Application of single-cell technologies (e.g.. single-cell RNA-sequencing) for the analysis of tissue cell composition, with a special focus on the identification and molecular characterization of "cancer stem cells” populations in epithelial malignancies (e.g., colon cancer, breast cancer, adenoid cystic carcinomas of the salivary glands), as well as their normal counterparts in healthy tissues (i.e. stem cells of the intestinal, mammary and salivary gland epithelia).

Research Interests:

  • Predictive biomarkers in medical oncology
  • Cancer stem cells
  • Colon cancer
  • Breast cancer
  • Adenoid cystic carcinomas of the salivary glands

Links:

Selected Publications

  • Viragova S., Aparicio L., Zhao J., Valencia Salazar L.E., Schurer A., Dhuri A., Sahoo D., Moskaluk C.A., Rabadan R. and Dalerba P. Phenotypic dissection of epithelial lineages and therapeutic manipulation of differentiation programs in human Adenoid Cystic Carcinomas (ACCs). bioRxiv, posted: January 21, 2022, https://www.biorxiv.org/content/10.1101/2022.01.19.476843v1
  • Dalerba P. Estimating the Economic Value of CDX2 as a Predictive Biomarker to Guide Treatment Decisions in Stage II Colon Cancer. Value in Health, 25:382-384 (2022)
  • Raab W.J. Mazzocchi A. Radice P. Sahoo D. Castelli C. and Dalerba P. A microsatellite in the coding sequence of HLA-A/B is a mutation hotspot in colon cancer with microsatellite instability. Gastroenterology, 162:960-963 (2022). PMID: 34653421. 
  • Dalerba P., Bruce Levin , John L Thompson. A Trial of Lopinavir-Ritonavir in Covid-19. N Engl J Med. 2020 May 21;382(21):e68.
  • Bettina Kunze, Frederik Wein, Hsin-Yu Fang, Akanksha Anand, Theresa Baumeister, Julia Strangmann, Sophie Gerland, Jonas Ingermann, Natasha Stephens Münch, Maria Wiethaler, Vincenz Sahm, Ana Hidalgo-Sastre, Sebastian Lange, Charles J Lightdale, Aqiba Bokhari, Gary W Falk, Richard A Friedman, Gregory G Ginsberg, Prasad G Iyer, Zhezhen Jin, Hiroshi Nakagawa, Carrie J Shawber, TheAnh Nguyen, William J Raab, Piero Dalerba, Anil K Rustgi, Antonia R Sepulveda, Kenneth K Wang, Roland M Schmid, Timothy C Wang, Julian A Abrams, Michael. QuanteNotch Signaling Mediates Differentiation in Barrett's Esophagus and Promotes Progression to Adenocarcinoma. Gastroenterology. 2020 Aug;159(2):575-590.
  • Junko Mukohyama, Taichi Isobe, Qingjiang Hu, Takanori Hayashi, Takashi Watanabe, Masao Maeda, Hisano Yanagi, Xin Qian, Kimihiro Yamashita, Hironobu Minami, Koshi Mimori, Debashis Sahoo, Yoshihiro Kakeji, Akira Suzuki, Piero Dalerba, Yohei Shimono. miR-221 Targets QKI to Enhance the Tumorigenic Capacity of Human Colorectal Cancer Stem Cells. Cancer Res. 2019 Oct 15;79(20):5151-5158.
  • Mara Roxana Rubinstein, Jung Eun Baik, Stephen M Lagana, Richard P Han, William J Raab, Debashis Sahoo, Piero Dalerba, Timothy C Wang, Yiping W Han. Fusobacterium nucleatum promotes colorectal cancer by inducing Wnt/β-catenin modulator Annexin A1. EMBO Rep. 2019 Apr;20(4):e47638.
  • Itamar Kanter, Piero Dalerba, Tomer Kalisky. A cluster robustness score for identifying cell subpopulations in single cell gene expression datasets from heterogeneous tissues and tumors. Bioinformatics. 2019 Mar 15;35(6):962-971.
  • Dalerba P. The dynamic identity of intestinal cancer stem cells. Cell Stem Cell, 20:743-745 (2017). PubMed ID: 28575688
  • Dalerba P., Sahoo D., Paik S., Guo X., Yothers G., Song N., Wilcox-Fogel N., Forgo' E., Rajendran P.S., Miranda S.P., Hisamori S., Hutchison J., Kalisky T., Qian D., Wolmark N., Fisher G.A., van de Rijn M. and Clarke M.F. CDX2 as a prognostic biomarker in Stage-II and Stage-III colon cancer. The New England Journal of Medicine (N.E.J.M.), 374:211-222 (2016). PubMed ID: 26789870
  • Cominelli M., Grisanti S., Mazzoleni S., Branca C., Buttolo L., Furlan D., Liserre B., Bonetti M.F., Medicina D., Pellegrini V., Buglione M., Liserre R., Pellegatta S., Finocchiaro G., Dalerba P., Facchetti F., Pizzi M., Galli R. and Poliani P.L. EGFR amplified and overexpressing glioblastomas and association with better response to adjuvant metronomic temozolomide. Journal of the National Cancer Institute (J.N.C.I.), 107:djv041 (2015). PubMed ID: 25739547
  • Wu A.R., Neff N.F., Kalisky T., Dalerba P., Treutlein B., Rothenberg M.E., Mburu F.M., Mantalas G.L., Sim S., Clarke M.F. and Quake S.R. Quantitative assessment of single-cell RNA-sequencing methods. Nature Methods, 11:41-46 (2014). PubMed ID: 24141493
  • Dalerba P. and Clarke M.F. Oncogenic miRNAs and the perils of losing control of a stem cell's epigenetic identity. Cell Stem Cell, 13:5-6 (2013). PubMed ID: 23827702
  • Willingham S., Volkmer J.P., Gentles A.J., Sahoo D., Dalerba P., Mitra S.S., Wang J., Contreras-Trujillo H., Martin R., Cohen J.D., Lovelace P., Scheeren F.A., Chao M.P., Weisskopf K., Tang C., Naik T.J., Volkmer A., Storm T.A., Mosley A.R., Edris B., Schmid S.M., Sun C.K., Chua M.S., Murillo O., Rajendran P.S., Cha A.C., Chin R.K., Kim D., Adorno M., Raveh T., Tseng D., Jaiswal S., Enger P.O., Steinberg G.K., Li G., So S.K., Majeti R., Harsh G.R., van de Rijn M., Teng N., Sunwoo J.B., Alizadeh A.A., Clarke M.F. and. Weissman I.L. The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proceedings of the National Academy of Sciences of the USA (P.N.A.S.), 109:6662-6667 (2012). PubMed ID: 22451913
  • Dalerba P., Kalisky T., Sahoo D., Rajendran P.S., Rothenberg M.E., Leyrat A.A., Sim S., Okamoto J., Johnston D.M., Qian D., Zabala M., Bueno J., Neff N.F., Wang J., Shelton A.A., Visser B., Hisamori S., Shimono Y., van de Wetering M., Clevers H., Clarke M.F. and Quake S.R. Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nature Biotechnology, 29:1120-1127 (2011). PubMed ID: 22081019
  • Shimono Y., Zabala M., Cho R.W., Lobo N.A., Dalerba P., Qian D., Diehn M., Liu H., Panula S.P., Chiao E., Dirbas F.M., Somlo G., Pera R.A., Lao K. and Clarke M.F. Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell, 138:592-603 (2009). PubMed ID: 19665978
  • Dalerba P., Dylla S.J., Park I.K., Liu R., Wang X., Cho R.W., Hoey T., Gurney A., Huang E.H., Simeone D.M., Shelton A.A., Parmiani G., Castelli C. and Clarke M.F. Phenotypic characterization of human colorectal cancer stem cells. Proceedings of the National Academy of Sciences of the USA (P.N.A.S.), 104:10158-10163 (2007). PubMed ID: 17548814
  • Liu R., Wang X., Chen G.Y., Dalerba P., Gurney A., Hoey T., Sherlock G., Lewicki J., Shedden K. and Clarke M.F. The prognostic role of a gene signature from tumorigenic breast cancer cells. The New England Journal of Medicine (N.E.J.M.), 356:217-226 (2007). PubMed ID: 17229949
  • Dalerba P. and Clarke M.F. Cancer stem cells and tumor metastasis: first steps into uncharted territory. Cell Stem Cell, 1:241-242 (2007). PubMed ID: 18371356
  • Dalerba P., Cho R.W. and Clarke M.F. Cancer stem cells: models and concepts. Annual Review of Medicine, 58:267-284 (2007). PubMed ID: 17002552
  • Dalerba P., Guiducci C., Poliani P.L., Cifola I., Parenza M., Frattini M., Gallino G., Carnevali I., Di Giulio I., Andreola S., Lombardo C., Rivoltini L., Schweighoffer T., Belli F., Colombo M.P., Parmiani G. and Castelli C. Reconstitution of human telomerase reverse transcriptase (hTERT) expression rescues colorectal carcinoma cells from in vitro senescence: evidence against immortality as a constitutive trait of tumor cells. Cancer Research, 65:2321-2329 (2005). PubMed ID: 15781646

For a complete list of publications, please visit PubMed.gov